01 February 2023: Lab/In Vitro Research
Neutrophil-to-Platelet Ratio in Patients with Ulcerative Colitis Treated with Infliximab or Vedolizumab: A Retrospective, Single-Center Study in Poland
Marcin Warpechowski 1CD* , Jędrzej Warpechowski 2AEF , Anita Pieńkowska 2BEF , Szymon Sagała 2BEF , Robert Milewski 1CDEDOI: 10.12659/MSM.938827
Med Sci Monit 2023; 29:e938827
Table 2 Differences between ulcerative colitis patients with sustained response and loss of response to Vedolizumab or Infliximab. (Word 2016, Microsoft Office).
| Sustained response | Loss of response | P value | |
|---|---|---|---|
| Number of patients | 22 | 13 | |
| Gender: male/female | 16/6 | 11/2 | 0.578 |
| Age at diagnosis, median (interquartile range) | 23 (18–35) years | 30 (23–39) years | 0.229 |
| Age at start of therapy, median (interquartile range) | |||
| Vedolizumab | 25 (21–42) years | 42 (30–58.5) years | 0.033 |
| Infliximab | 37 (28–44) years | 40 (40–54) years | 0.583 |
| Disease duration, median (interquartile range) | 4 (3–11) | 9 (8–15) | 0.091 |
| UC location: proctitis/left-sided/pancolitis | 2/8/12 | 0/7/6 | 1 |
| Contaminant therapies, n % | |||
| Immunomodulators | 3 (13.6%) | 6 (46,.1%) | 0.113 |
| Corticosteroids | 2 (9.1%) | 4 (30.8%) | 0.302 |
| Mesalamine | 11 (50%) | 10 (76.9%) | 0.191 |
| Sulfasalazine | 1 (4.5%) | 1 (7.7%) | 0.932 |
| Partial Mayo score, median (interquartile range) | 6 (5–7) | 7 (6–8) | 0.158 |
| WBC (/μl), median (interquartile range) | 7950 (6025–9380) | 8460 (5647–9547) | 0.749 |
| Platelet (×10/μl), median (interquartile range) | 257 (221–301) | 241 (198–274) | 0.215 |
| Neutrophils (×10/μl), median (interquartile range) | 4.718 (3.217–5.55) | 4.334 (3.409–6.169) | 0.853 |
| Hemoglobin (g/dl), median (interquartile range) | 13.25 (11.7–14.8) | 14.3 (13.5–14.8) | 0.098 |
| CRP (mg/l), median (interquartile range) | 2.75 (1.7–6.4) | 2.6 (1–5.6) | 0.625 |
| MPV (fl), median (interquartile range) | 9.9 (9.3–10.8) | 10.1 (8.6–10.8) | 0.624 |
| Neutrophil-platelet ratio, median (interquartile range) | 13.63 (11.85–17.01) | 19.41 (16.88–21.67) | 0.007 |
| UC – ulcerative colitis, WBC – white blood cells, CRP – C-reactive protein, MPV – mean platelet volume, μl – microliters, g/dl – grams per deciliter, mg/l – milligrams per liter, fl – femtoliters. | |||