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11 April 2023: Clinical Research

Intraoperative Hypotension and Its Association with Postoperative Acute Kidney Injury in Patients Undergoing Pancreaticoduodenectomy: A 5-Year, Single-Center, Retrospective Cohort Study

Zbigniew Putowski 1ABCDEF* , Karolina Majewska 12ABCDE , Karol Gruca 1ABCD , Aleksandra Zimnoch 1ABC , Anna Szczepańska 3DEF , Łukasz J. Krzych 3ABCDE , Beata Jabłońska 4DEF , Sławomir Mrowiec 4DEF

DOI: 10.12659/MSM.938945

Med Sci Monit 2023; 29:e938945

Table 1 Patient-related factors associated with postoperative AKI.

VariablePostoperative AKI (−)Postoperative AKI (+)P value
Age (yr)63.5 (57.0–69.0)67.0 (61.0–73.0)
Male (yes/no)123 (50.6)31 (53.4)0.7
BMI (kg·m)25.1 (22.3–28.0)25.8 (22.5–28.4)0.3
Neoadjuvant chemotherapy (yes/no)14 (6.0)7 (12.3)0.1
Chronic kidney disease (yes/no)2 (0.9)2 (3.7)0.2
Coronary heart disease (yes/no)16 (6.9)9 (16.4)
Diabetes mellitus (yes/no)63 (26.8)13 (23.6)0.8
Preoperative hemoglobin (g dL)13.4 (12.5–14.3)12.9 (12.2–13.9)0.17
Preoperative creatinine (mg dL)0.86 (0.77–0.98)0.88 (0.78–0.98)0.6
Chronic arterial hypertension (yes/no)130 (55.8)38 (69.1)0.0725
ACEI/ARB (yes/no)70 (30.4)24 (44.4)
Beta-blocker (yes/no)86 (37.4)22 (40.7)0.6
Calcium antagonist (yes/no)30 (13.0)6 (11.1)0.7
Diuretics (yes/no)30 (13.0)9 (16.7)0.5
I (yes/no)4 (1.6)0 (0.0)1
II (yes/no)120 (49.4)20 (34.5)
III (yes/no)115 (47.3)38 (65.5)
IV (yes/no)3 (1.2)0 (0.0)1
CCI (points)4 (3–5)5 (4–6)
RCRI (points)1 (1–2)1 (1–2)0.6
Premedication (yes/no)188 (77.4)39 (67.2)0.1
Preinduction MAP (mmHg)102.0 (92.1–110.8)107.8 (96.7–117.7)
Continuous variables are expressed as median and interquartile range (in brackets). Qualitative variables are expressed as absolute values and/or percent (in brackets). BMI – body mass index; CCI – Charlson Comorbidity Index; ACEI/ARB – angiotensin-converting enzyme inhibitors/angiotensin receptor blockers; MAP – mean arterial pressure; AKI – acute kidney injury; RCRI – revised cardiac risk index.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750