11 April 2023: Clinical Research
Intraoperative Hypotension and Its Association with Postoperative Acute Kidney Injury in Patients Undergoing Pancreaticoduodenectomy: A 5-Year, Single-Center, Retrospective Cohort Study
Zbigniew Putowski 1ABCDEF* , Karolina Majewska 12ABCDE , Karol Gruca 1ABCD , Aleksandra Zimnoch 1ABC , Anna Szczepańska 3DEF , Łukasz J. Krzych 3ABCDE , Beata Jabłońska 4DEF , Sławomir Mrowiec 4DEFDOI: 10.12659/MSM.938945
Med Sci Monit 2023; 29:e938945
Table 2 Procedure-related factors associated with postoperative AKI.
| Variable | Postoperative AKI (−) | Postoperative AKI (+) | P value |
|---|---|---|---|
| Anesthesia duration (min) | 495 (415–550) | 512 (410–570) | 0.2 |
| Procedure duration (min) | 435 (375–490) | 457 (365–505) | 0.16 |
| Adjunction of regional anesthesia (yes/no) | 76 (31.3) | 17 (29.3) | 0.8 |
| Fluid dose (mL·kg·h) | 6.39 (5.00–8.36) | 5.97 (4.97–7.71) | 0.6 |
| Bleeding (mL·kg·h) | 0.81 (0.45–1.72) | 0.93 (0.51–1.74) | 0.7 |
| Intraoperative diuresis (mL·kg·h) | 0.72 (0.49–1.09) | 0.59 (0.41–0.90) | |
| Transfusion of blood products (yes/no) | 60 (34.5) | 16 (41.0) | 0.4 |
| Minimal MAP (mmHg) | 63.3 (58.3–68.0) | 61.7 (56.7–68.0) | 0.16 |
| Median MAP (mmHg) | 83.2 (79.5–86.9) | 83.3 (78.3–87.7) | 0.9 |
| Max.% drop from preinduction MAP | 37.7 (30.6–44.5) | 42.7 (37.0–50.0) | |
| MAP | 25 (10.3) | 13 (22.4) | |
| Duration of MAP | 0.0 (0.0–0.0) | 0.0 (0.0–0.0) | |
| MAP | 70 (28.8) | 23 (39.7) | 0.11 |
| Duration of MAP | 0.0 (0.0–5.0) | 0.0 (0.0–5.0) | 0.13 |
| MAP | 141 (58.0) | 36 (62.1) | 0.6 |
| Duration of MAP | 5.0 (0.0–12.5) | 5.0 (0.0–20.0) | 0.23 |
| MAP | 205 (84.4) | 50 (86.2) | 0.7 |
| Duration of MAP | 20.0 (5.0–40.0) | 25.0 (5.0–60.0) | 0.2 |
| Norepinephrine (yes/no) | 182 (75.2) | 48 (84.2) | 0.14 |
| Norepinephrine dose (ug kg min) | 0.08 (0.04–0.14) | 0.11 (0.07–0.15) | |
| Continuous variables are expressed as median and interquartile range (in brackets). Qualitative variables are expressed as absolute values and/or percent (in brackets). MAP – mean arterial pressure; AKI – acute kidney injury. | |||