Intraoperative Hypotension and Its Association with Postoperative Acute Kidney Injury in Patients Undergoing Pancreaticoduodenectomy: A 5-Year, Single-Center, Retrospective Cohort Study

11 April 2023 : Clinical Research

Zbigniew Putowski^1ABCDEF*, Karolina Majewska

^12ABCDE, Karol Gruca^1ABCD, Aleksandra Zimnoch^1ABC, Anna Szczepańska

^3DEF, Łukasz J. Krzych^3ABCDE, Beata Jabłońska^4DEF, Sławomir Mrowiec^4DEF

DOI: 10.12659/MSM.938945

Med Sci Monit 2023; 29:e938945

Background Material and Methods Results Discussion Conclusions References

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Table 2 Procedure-related factors associated with postoperative AKI.

Variable	Postoperative AKI (−)	Postoperative AKI (+)	P value
Anesthesia duration (min)	495 (415–550)	512 (410–570)	0.2
Procedure duration (min)	435 (375–490)	457 (365–505)	0.16
Adjunction of regional anesthesia (yes/no)	76 (31.3)	17 (29.3)	0.8
Fluid dose (mL·kg·h)	6.39 (5.00–8.36)	5.97 (4.97–7.71)	0.6
Bleeding (mL·kg·h)	0.81 (0.45–1.72)	0.93 (0.51–1.74)	0.7
Intraoperative diuresis (mL·kg·h)	0.72 (0.49–1.09)	0.59 (0.41–0.90)
Transfusion of blood products (yes/no)	60 (34.5)	16 (41.0)	0.4

Minimal MAP (mmHg)	63.3 (58.3–68.0)	61.7 (56.7–68.0)	0.16
Median MAP (mmHg)	83.2 (79.5–86.9)	83.3 (78.3–87.7)	0.9
Max.% drop from preinduction MAP	37.7 (30.6–44.5)	42.7 (37.0–50.0)
MAP <55 mmHg (yes/no)	25 (10.3)	13 (22.4)
Duration of MAP <55 mmHg (min)	0.0 (0.0–0.0)	0.0 (0.0–0.0)
MAP <60 mmHg (yes/no)	70 (28.8)	23 (39.7)	0.11
Duration of MAP <60 mmHg (min)	0.0 (0.0–5.0)	0.0 (0.0–5.0)	0.13
MAP <65 mmHg (yes/no)	141 (58.0)	36 (62.1)	0.6
Duration of MAP <65 mmHg (min)	5.0 (0.0–12.5)	5.0 (0.0–20.0)	0.23
MAP <70 mmHg (yes/no)	205 (84.4)	50 (86.2)	0.7
Duration of MAP <70 mmHg (min)	20.0 (5.0–40.0)	25.0 (5.0–60.0)	0.2

Norepinephrine (yes/no)	182 (75.2)	48 (84.2)	0.14
Norepinephrine dose (ug kg min)	0.08 (0.04–0.14)	0.11 (0.07–0.15)
Continuous variables are expressed as median and interquartile range (in brackets). Qualitative variables are expressed as absolute values and/or percent (in brackets). MAP – mean arterial pressure; AKI – acute kidney injury.

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