27 January 2023: Clinical Research
Impact of Perioperatively Administered Amino Acids, Lidocaine, and Magnesium on Inflammatory Response and Pain Associated with Abdominal Surgery: A Prospective Clinical Study
Ognjenka Sarenac 12ABDEF , Ranko Lazovic 23BDEF , Batric Vukcevic 23BCE* , Jelena R. Lazovic 4BCDE , Ivan G. Palibrk 5ADEFDOI: 10.12659/MSM.939204
Med Sci Monit 2023; 29:e939204
Table 1 Preoperative parameters in Group 1 and Group 2 (statistically significant differences are in bold; P<0.05).
| Parameter | Group 1 (n=50) | Group 2 (n=50) | p-value |
|---|---|---|---|
| Sex (n (%)) | |||
| Male | 30 (60.0) | 25 (50.0) | |
| Female | 20 (40.0) | 25 (50.0) | 0.315* |
| Age in years (mean (SD)) | 61.71±9.61 | 63.72±11.30 | 0.452** |
| Indication for surgery (n (%)) | |||
| Rectal cancer | 20 (40.0) | 21 (42.0) | |
| Ovarian cancer | 2 (4.0) | 1 (2.0) | |
| Colon cancer | 12 (24.0) | 7 (14.0) | |
| Hepatocellular carcinoma | 3 (6.0) | 7 (14.0) | |
| Pancreatic cancer | 3 (6.0) | 4 (8.0) | |
| Gastric cancer | 4 (8.0) | 3 (6.0) | |
| Carcinoma of the small intestine | 1 (2.0) | 2 (4.0) | |
| Other | 5 (10.0) | 5 (10.0) | 0.792* |
| Body weight (kg) (mean (SD)) | 80.12±20.563 | 76.50±15.73 | 0.497** |
| Body height (cm) (mean (SD)) | 173.45±6.87 | 172.20±6.77 | 0.395** |
| BMI (kg/m) (mean (SD)) | 26.77±6.66 | 25.67±4.47 | 0.795** |
| WBC count (10/l) (mean (SD)) | 7.79±3.30 | 8.49±3.15 | 0.215** |
| Neutrophil count (10/l) (mean (SD)) | 5.57±3.20 | 6.23±2.73 | 0.089** |
| Lymphocyte count (10/l) (mean (SD)) | 1.51±1.67 | 1.18±0.71 | 0.181** |
| PLT count (10/l) (mean (SD)) | 259.63±75.37 | 225.00±107.43 | ** |
| Fibrinogen level (g/l) (mean (SD)) | 3.57±0.95 | 3.40±1.09 | 0.359** |
| CRP level (mg/l) (mean (SD)) | 29.53±41.88 | 47.72±60.35 | 0.055** |
| IL-6 level (pg/ml) (mean (SD)) | 48.10±37.92 | 107.76±188.05 | ** |
| PCT level (ng/ml) (mean (SD)) | 0.29±0.46 | 0.27±0.41 | 0.988** |
| * Chi-squared test; ** Mann-Whitney U-test. | |||