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27 January 2023 : Clinical Research  

Impact of Perioperatively Administered Amino Acids, Lidocaine, and Magnesium on Inflammatory Response and Pain Associated with Abdominal Surgery: A Prospective Clinical Study

Ognjenka Sarenac12ABDEF, Ranko Lazovic23BDEF, Batric Vukcevic32BCE*, Jelena R. Lazovic4BCDE, Ivan G. Palibrk5ADEF

DOI: 10.12659/MSM.939204

Med Sci Monit 2023; 29:e939204

Table 1 Preoperative parameters in Group 1 and Group 2 (statistically significant differences are in bold; P<0.05).

ParameterGroup 1 (n=50)Group 2 (n=50)p-value
Sex (n (%))
 Male30 (60.0)25 (50.0)
Female20 (40.0)25 (50.0)0.315*
Age in years (mean (SD))61.71±9.6163.72±11.300.452**
Indication for surgery (n (%))
 Rectal cancer20 (40.0)21 (42.0)
 Ovarian cancer2 (4.0)1 (2.0)
 Colon cancer12 (24.0)7 (14.0)
 Hepatocellular carcinoma3 (6.0)7 (14.0)
 Pancreatic cancer3 (6.0)4 (8.0)
 Gastric cancer4 (8.0)3 (6.0)
 Carcinoma of the small intestine1 (2.0)2 (4.0)
 Other5 (10.0)5 (10.0)0.792*
Body weight (kg) (mean (SD))80.12±20.56376.50±15.730.497**
Body height (cm) (mean (SD))173.45±6.87172.20±6.770.395**
BMI (kg/m) (mean (SD))26.77±6.6625.67±4.470.795**
WBC count (10/l) (mean (SD))7.79±3.308.49±3.150.215**
Neutrophil count (10/l) (mean (SD))5.57±3.206.23±2.730.089**
Lymphocyte count (10/l) (mean (SD))1.51±1.671.18±0.710.181**
PLT count (10/l) (mean (SD))259.63±75.37225.00±107.43**
Fibrinogen level (g/l) (mean (SD))3.57±0.953.40±1.090.359**
CRP level (mg/l) (mean (SD))29.53±41.8847.72±60.350.055**
IL-6 level (pg/ml) (mean (SD))48.10±37.92107.76±188.05**
PCT level (ng/ml) (mean (SD))0.29±0.460.27±0.410.988**
* Chi-squared test;
** Mann-Whitney U-test.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750