03 April 2023: Clinical Research
Evaluation of a Previously Developed Predictive Model for Infective Endocarditis in 320 Patients Presenting with Fever at 4 Centers in Japan Between January 2018 and December 2020
Shun Yamashita 1ABCDEF* , Masaki Tago 1ACDEF , Yoshinori Tokushima 1BCDF , Yukinori Harada 2ABD , Yudai Suzuki 2ABCD , Yuki Aizawa 2ABCD , Taiju Miyagami 3ABCD , Fumiaki Sano 3ABCD , Yosuke Sasaki 4ABCD , Fumiya Komatsu 4ABCD , Taro Shimizu 2BCD , Toshio Naito 3BCD , Yoshihisa Urita 4BCD , Shu-ichi Yamashita 1BCDEDOI: 10.12659/MSM.939640
Med Sci Monit 2023; 29:e939640
Table 1 Univariate analysis of patient characteristics.
| Total(N=320) | IE(N=119) | UF(N=201) | p value | |
|---|---|---|---|---|
| Age, years | 69 (56–79) | 70 (58–78) | 69 (52–79) | 0.715 |
| Male | 177 (55) | 80 (67) | 97 (48) | 0.001 |
| Duration of hospital stay | 21 (10–47) | 46 (25–60) | 15 (9–25) | |
| Mortality | ||||
| 30-day mortality | 18/307 (6) | 13/117 (11) | 5/189 (3) | 0.002 |
| In-hospital mortality | 26 (8) | 21 (18) | 5 (3) | |
| Transfer by ambulance | 98 (31) | 46 (39) | 52 (26) | 0.016 |
| Administration of antibiotics# | 86/319 (27) | 23 (19) | 63/200 (32) | 0.018 |
| Past medical history | ||||
| Previous IE | 13 (4) | 11 (9) | 2 (1) | |
| Prosthetic valve | 49/316 (16) | 36 (30) | 13/197 (7) | |
| Chronic dermatological disorder | 26 (8) | 16 (13) | 10 (5) | 0.007 |
| Chronic kidney disease | 57 (18) | 24 (20) | 33 (16) | 0.397 |
| Hemodialysis | 28 (9) | 14 (12) | 14 (7) | 0.142 |
| Diabetes mellitus | 59 (18) | 22 (18) | 37 (18) | 0.986 |
| Use of steroids | 24 (8) | 4 (3) | 20 (10) | 0.031 |
| Use of immunosuppressant agents | 27 (8) | 7 (6) | 20 (10) | 0.201 |
| Malignancy | 57 (18) | 21 (18) | 36 (18) | 0.953 |
| Dental problems* | 70/171 (41) | 41/82 (50) | 29/89 (33) | 0.021 |
| Dentistry going to hospital** | 29/136 (21) | 19/68 (28) | 10/68 (15) | 0.060 |
| Invasive dental treatment history** | 13/135 (10) | 9/68 (13) | 4/67 (6) | 0.153 |
| Cardiac murmur | 92/297 (31) | 70/110 (64) | 22/187 (12) | |
| Chest x-ray | ||||
| Pulmonary edema | 23/316 (7) | 16 (13) | 7/197 (4) | 0.001 |
| Pleural effusion | 90/316 (28) | 47 (39) | 43/197 (22) | 0.001 |
| Categorical data are expressed as n (%) and were compared using the χ test. Continuous variables are expressed as median (interquartile range) and were compared using the Mann-Whitney test. IE – infective endocarditis; UF – undiagnosed fever. # Before obtaining blood culture samples; * including caries, periodontitis, tooth defect, and poor oral hygiene; ** within 6 months. | ||||