03 April 2023: Clinical Research
Evaluation of a Previously Developed Predictive Model for Infective Endocarditis in 320 Patients Presenting with Fever at 4 Centers in Japan Between January 2018 and December 2020
Shun Yamashita 1ABCDEF* , Masaki Tago 1ACDEF , Yoshinori Tokushima 1BCDF , Yukinori Harada 2ABD , Yudai Suzuki 2ABCD , Yuki Aizawa 2ABCD , Taiju Miyagami 3ABCD , Fumiaki Sano 3ABCD , Yosuke Sasaki 4ABCD , Fumiya Komatsu 4ABCD , Taro Shimizu 2BCD , Toshio Naito 3BCD , Yoshihisa Urita 4BCD , Shu-ichi Yamashita 1BCDEDOI: 10.12659/MSM.939640
Med Sci Monit 2023; 29:e939640
Table 2 Univariate analysis of vital signs and laboratory findings on admission.
| Total(N=320) | IE(N=119) | UF(N=201) | p value | |
|---|---|---|---|---|
| Vital signs on admission | ||||
| Pulse rate (beats/min) | 90 (80–106) | 90 (75–108) | 91 (80–105) | 0.692 |
| Systolic blood pressure (mmHg) | 120 (106–132) | 116 (105–127) | 121 (108–137) | 0.016 |
| Diastolic blood pressure (mmHg) | 69 (60–79) | 68 (58–77) | 70 (60–80) | 0.156 |
| Respiratory rate (beats/min) | 20 (16–22) | 20 (16–24) | 19 (16–21) | 0.036 |
| Oxygen saturation (%) | 97 (96–98) | 97 (95–98) | 98 (96–98) | 0.422 |
| Body temperature (°C) | 37.5 (36.9–38.4) | 37.4 (36.8–38.3) | 37.6 (36.9–38.4) | 0.162 |
| Laboratory findings on admission | ||||
| White blood cell count (×10/μL) | 9.3 (6.4–13.0) | 9.9 (7.7–14.2) | 8.4 (5.1–12.5) | 0.001 |
| Neutrophil count (%)6 | 82.3 (74.5–88.5) | 86.8 (81.7–91.7) | 79.2 (69.8–86.1) | |
| Platelet count (×10/μL) | 18.3 (13.1–26.2) | 15.1 (11.2–21.7) | 20.5 (14.7–31.5) | |
| Albumin (g/dL) | 3.0 (2.6–3.5) | 2.9 (2.5–3.4) | 3.1 (2.6–3.6) | 0.021 |
| Total bilirubin (mg/dL) | 0.7 (0.5–1.0) | 0.7 (0.5–1.1) | 0.7 (0.4–0.9) | 0.013 |
| AST (IU/L) | 30.0 (20.0–45.0) | 28.0 (20.0–39.0) | 31.0 (20.0–49.5) | 0.750 |
| ALT (IU/L) | 21.0 (13.0–35.0) | 21 (13–34) | 21.0 (13.0–36.0) | 0.796 |
| LDH (IU/L) | 248.0 (198.0–316.0) | 275.0 (223.0–367.0) | 238.5 (180.0–299.5) | |
| BUN (mg/dL) | 17.0 (12.0–27.0) | 21.0 (13.0–35.1) | 15.0 (11.0–23.2) | |
| Creatinine (mg/dL) | 0.9 (0.7–1.3) | 0.9 (0.7–1.5) | 0.8 (0.6–1.1) | 0.002 |
| C-reactive protein (mg/dL) | 8.3 (3.6–14.9) | 8.3 (4.1–17.0) | 8.6 (3.2–14.3) | 0.427 |
| Continuous variables are expressed as median (interquartile range) and were compared using the Mann-Whitney test. IE – infective endocarditis; UF – undiagnosed fever; AST – aspartate aminotransferase; ALT – alanine aminotransferase; LDH – lactate dehydrogenase; BUN – blood urea nitrogen. | ||||