Influence of Umbilical Cord Blood Biochemical Parameters and Disease Condition on the Expression of the TSG-6 Gene in Umbilical Mesenchymal Stem Cells

Aleksandra Ozygała; Gabriela Wojciechowska; Kinga Traczyk; Dominika Przywara; Alicja Petniak; Rafał Szymanowski; Agnieszka Wilińska; Arkadiusz Krzyżanowski; Anna Kwaśniewska; Bartosz J. Płachno; Paulina Gil-Kulik; Janusz Kocki

doi:10.12659/MSM.939716

14 June 2023: Clinical Research

Influence of Umbilical Cord Blood Biochemical Parameters and Disease Condition on the Expression of the Gene in Umbilical Mesenchymal Stem Cells

Aleksandra Ozygała ^1ABDEFG , Gabriela Wojciechowska ^1BDEF , Kinga Traczyk ^1BDEF , Dominika Przywara ^23ABDEF , Alicja Petniak ^2BDEF , Rafał Szymanowski ^2BE , Agnieszka Wilińska ^2BE , Arkadiusz Krzyżanowski ^4BF , Anna Kwaśniewska ^4BF , Bartosz J. Płachno ^5EF , Paulina Gil-Kulik ^2ABCDEF** , Janusz Kocki ^2ADEG*

DOI: 10.12659/MSM.939716

Med Sci Monit 2023; 29:e939716

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Table 4 Correlations between clinical parameters and expression of genes in the group of healthy women (n=17), patients with gestational diabetes (n=13), patients with hypertension (n=8), and patients with hypothyroidism (n=14).

Parameter	RQ IL1A	RQ IL1B	RQ IL1R1	RQ IL2	RQ IL6	RQ IL6R	RQ TSG-6

RQ	1.000	^*	0.009	−^*	^*	−0.420	0.090
RQ	^*	1.000	−0.081	−0.269	^*	−0.390	^*
RQ	0.009	−0.081	1.000	0.392	0.364	^*	−0.087
RQ	−^*	−0.269	0.392	1.000	−0.336	^*	0.019
RQ	^*	^*	0.364	−0.336	1.000	−0.019	0.031
RQ	−0.420	−0.390	^*	^*	−0.019	1.000	−0.162
RQ	0.090	^*	−0.087	0.019	0.031	−0.162	1.000
Mother’s age	0.010	0.074	−0.316	−0.367	−0.056	−0.502	−0.066
Number of pregnancies	−0.436	0.147	0.052	0.035	−0.289	0.089	0.322
Number of deliveries	−0.356	0.338	−0.026	0.120	−0.267	0.071	^*
Weeks of gestation	0.210	0.118	0.066	−0.314	0.188	−0.231	−0.027
Newborn’s weight	0.270	0.079	0.318	−0.135	0.200	0.091	−0.049
pH	−^*	−0.104	−0.028	0.466	−^*	0.186	0.012
pCO	^*	0.104	0.104	−0.458	^*	−0.116	0.037
PO	−0.226	0.154	−^*	0.026	−0.538	−0.364	0.198
cHCO	−0.512	0.117	0.318	0.352	−0.463	0.366	0.267
WBC	0.104	0.058	−0.124	0.303	−0.010	0.003	0.033
RBC	0.493	−0.071	−0.040	−0.081	^*	−0.146	−0.226
HGB	0.402	0.055	0.094	0.001	^*	−0.029	−0.109
HCT	0.492	0.080	0.032	−0.199	^*	−0.170	−0.087
MCH	0.025	0.205	0.209	0.067	0.129	0.128	0.150
MCV	0.066	0.334	0.156	−0.277	0.156	−0.079	0.305
MCHC	−0.027	−0.034	0.209	0.491	0.057	0.353	−0.100
PLT	0.312	0.603^*	−0.514	0.027	0.058	−^*	^*

RQ	1.000	0.143	0.390	−^*	0.533	0.000	0.467
RQ	0.143	1.000	−0.302	0.214	0.242	−0.214	−0.192
RQ	0.390	−0.302	1.000	−^*	0.236	0.363	^*
RQ	−^*	0.214	−^*	1.000	−0.548	−0.048	−0.190
RQ	0.533	0.242	0.236	−0.548	1.000	−0.505	0.231
RQ	0.000	−0.214	0.363	−0.048	−0.505	1.000	−0.011
RQ	0.467	−0.192	^*	−0.190	0.231	−0.011	1.000
Mother’s age	0.468	0.108	−0.158	−0.470	0.119	−0.376	0.177
Number of pregnancies	−0.162	0.102	−0.045	0.218	−0.142	−0.171	0.102
Number of deliveries	−0.085	0.295	−0.160	0.075	0.096	−0.475	0.111
Weeks of gestation	−0.182	0.367	−0.098	−0.282	−0.283	0.042	−0.498
Newborn’s weight	−0.099	0.060	−0.121	0.310	−0.099	−0.269	−0.363
pH	−0.463	0.064	−0.105	^*	−0.225	−0.155	−0.022
pCO	^*	0.038	0.236	−0.667	0.253	−0.011	0.368
PO	−0.388	0.187	−0.061	0.262	−0.325	0.294	−0.025
cHCO	^*	0.052	0.305	−0.503	0.319	−0.157	^*
WBC	−0.159	0.005	−0.236	−0.405	−0.181	0.104	−0.440
RBC	0.137	0.374	−0.110	0.048	0.033	0.088	−0.088
HGB	0.171	0.011	0.094	−0.415	0.017	−0.182	0.039
HCT	−0.044	0.231	−0.170	−0.095	−0.066	0.000	−0.242
MCH	−0.165	−0.527	0.170	−0.429	−0.170	−0.038	−0.209
MCV	−0.154	−0.437	0.052	−0.357	−0.223	−0.135	−0.275
MCHC	0.270	−0.278	0.190	−0.119	−0.094	−0.253	0.273
PLT	−0.170	0.313	0.181	0.476	−0.176	0.379	0.038

RQ	1.000	0.392	0.413	0.231	−0.030	0.467	0.298
RQ	0.392	1.000	−0.123	−0.766	−0.005	^*	0.046
RQ	0.413	−0.123	1.000	0.142	0.841	0.067	^*
RQ	0.231	−0.766	0.142	1.000	−0.296	−0.748	−0.129
RQ	−0.030	−0.005	0.841	−0.296	1.000	0.159	0.942
RQ	0.467	^*	0.067	−0.748	0.159	1.000	0.232
RQ	0.298	0.046	^*	−0.129	0.942	0.232	1.000
Mother’s age	0.628	0.658	0.666	−0.451	0.620	0.788	0.779
Number of pregnancies	0.035	−0.109	0.904	−0.148	^*	0.067	^*
Number of deliveries	0.035	−0.109	0.904	−0.148	^*	0.067	^*
Weeks of gestation	−0.555	−0.234	−0.936	0.124	−0.815	−0.414	−^*
Newborn’s weight	−0.261	−^*	0.075	0.867	−0.131	−^*	−0.344
pH	0.619	−0.434	0.250	0.906	−0.296	−0.396	0.086
pCO	−0.750	0.022	0.068	−0.654	0.590	0.043	−0.015
PO	0.871	0.130	0.058	0.538	−0.463	0.135	−0.055
cHCO	−0.652	−0.441	0.420	−0.169	0.749	−0.357	0.056
WBC	0.825	0.159	−0.063	0.509	−0.562	0.140	−0.452
RBC	−0.693	0.223	−0.864	−0.525	−0.456	0.063	−0.776
HGB	0.813	0.429	0.787	−0.084	0.546	0.579	0.665
HCT	0.883	0.002	0.722	0.473	0.253	0.135	0.685
MCH	0.705	−0.211	0.859	0.524	0.445	−0.052	0.785
MCV	0.171	−0.563	0.889	0.477	0.698	−0.396	0.832
MCHC	−0.064	0.676	−0.815	−0.542	−0.637	0.523	−0.626
PLT	0.433	−0.557	0.054	^*	−0.451	−0.556	−0.549

RQ	1.000	0.302	0.547	−1.000	^*	−0.423	0.385
RQ	0.302	1.000	0.154	0.600	0.108	−0.007	−0.020
RQ	0.547	0.154	1.000	−0.800	0.392	0.110	^*
RQ	−1.000	0.600	−0.800	1.000	−0.700	0.600	−0.500
RQ	^*	0.108	0.392	−0.700	1.000	−^*	0.433
RQ	−0.423	−0.007	0.110	0.600	−^*	1.000	−0.134
RQ	0.385	−0.020	^*	−0.500	0.433	−0.134	1.000
Mother’s age	0.342	0.139	0.126	−0.500	0.220	−^*	0.097
Number of pregnancies	−0.361	0.282	−0.333	0.527	−0.370	−0.155	−0.356
Number of deliveries	−0.377	0.148	−0.275	0.632	−0.119	−0.237	−0.089
Weeks of gestation	^*	0.176	0.161	−0.707	0.464	−0.338	0.169
Newborn’s weight	0.275	0.059	−0.250	−0.616	0.400	−^*	−0.310
pH	0.006	−0.228	0.323	0.205	0.104	0.299	^*
pCO	0.044	0.086	−0.238	−0.300	−0.033	−0.336	−^*
PO	−0.110	0.160	0.319	0.300	−0.407	^*	0.314
cHCO	0.377	0.004	−0.117	−0.300	0.363	−^*	−0.101
WBC	0.033	−0.112	−0.176	0.500	0.130	−0.029	0.169
RBC	−0.503	0.042	−0.439	0.700	−0.414	0.137	−0.344
HGB	0.152	0.214	0.119	−0.500	0.293	−0.284	0.247
HCT	−0.154	0.187	0.070	−0.200	0.024	−0.037	0.073
MCH	0.501	0.113	^*	−^*	0.325	−0.102	0.356
MCV	^*	0.145	0.483	−^*	^*	−0.334	0.433
MCHC	^*	0.143	0.471	−^*	0.491	−0.337	0.372
PLT	−0.082	0.345	−0.062	0.700	−^*	0.459	−0.002
^* pH – potential of hydrogen; pO – partial pressure of oxygen; pCO – partial pressure of carbon dioxide; WBC – white blood cell count; RBC – red blood cell count; HGB – hemoglobin; HCT – hematocrit; MCV – mean corpuscular volume; MCH – mean corpuscular hemoglobin; MCHC – mean corpuscular hemoglobin concentration; PLT – platelet count; RQ – level of relative expression; SD – standard deviation; SE – standard error.

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Influence of Umbilical Cord Blood Biochemical Parameters and Disease Condition on the Expression of the Gene in Umbilical Mesenchymal Stem Cells

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