B-Type Natriuretic Peptide Can Distinguish Ischemic Stroke Subtypes Better than Other Cardiac Biomarkers

19 June 2023: Clinical Research

Ping Liang ^12ABCEF* , Shuang Han ^12ADG* , Yucen Jiang ^12B , Huikai Miao ^3BD* , Xiaowei Qi ^12ADG

DOI: 10.12659/MSM.939829

Med Sci Monit 2023; 29:e939829

Table 3 Diagnostic test results of IS patients.

Groups	Markers	Cut-off values	AUC (95% CI)	Sensitivity (%)	Specificity (%)	Youden Index
Diagnosis of SVO	BNP	37.5 pg/mL	0.725 (0.64–0.81)	0.537	0.39	0.757
	CK-MB	1.35 ng/mL	0.465 (0.37–0.56)	0.418	0.045	0.113
	cTnI	0.005 ng/mL	0.658 (0.57–0.75)	0.403	0.31	0.346
	MYO	35.75 ng/mL	0.409 (0.31–0.51)	0.164	0.124	0.144
	Combination		0.798 (0.73–0.87)	0.642	0.84	0.482
Diagnosis of LAA	BNP	41.5 pg/mL	0.808 (0.75–0.87)	0.654	0.88	0.534
	CK-MB	1.35 ng/mL	0.549 (0.47–0.63)	0.529	0.627	0.156
	cTnI	0.005 ng/mL	0.729 (0.66–0.8)	0.538	0.907	0.445
	MYO	42.15 ng/mL	0.537 (0.45–0.62)	0.192	0.987	0.179
	Combination		0.842 (0.79–0.9)	0.76	0.813	0.573
Diagnosis of CE	BNP	59 pg/mL	0.924 (0.87–0.98)	0.808	0.973	0.781
	CK-MB	2.25 ng/mL	0.806 (0.73–0.89)	0.635	0.893	0.528
	cTnI	0.005 ng/mL	0.919 (0.86–0.98)	0.885	0.907	0.792
	MYO	36.5 ng/mL	0.916 (0.85–0.98)	0.846	0.96	0.806
	Combination		0.993 (0.98–1)	0.942	0.987	0.929
SVO – small-vessel occlusion; LAA – large-artery atherosclerosis; CE – cardioembolism; BNP – B-type natriuretic peptide; CK-MB – creatine kinase-MB; cTnI – cardiac troponin I; MYO – myoglobin; AUC – area under the curve.