29 April 2023: Database Analysis
Clinical Course of 53 Previously Vaccinated Patients Admitted to the National Hospital in Warsaw, Poland with COVID-19 Between November 2021 and March 2022
Artur Zaczyński 1AB , Michał Hampel 1AB , Paweł Piątkiewicz 2AB* , Jacek Nasiłowski 3AB , Sławomir Butkiewicz 2AB , Urszula Religioni 4DEF , Agnieszka Barańska 5CD , Maria Malm 5CD , Agnieszka Neuman-Podczaska 6DEF , Regis Vaillancourt 2ACDF , Piotr Merks 2AFGDOI: 10.12659/MSM.939841
Med Sci Monit 2023; 29:e939841
Table 4 Severity of the course Of COVID-19 vs time since vaccination.
| Characteristic | N | Interval between the last dose and diagnose of COVID-19 [weeks]* | P value1 | ||||
|---|---|---|---|---|---|---|---|
| Overall, N=53 | [0,2], N=2 | [2,20], N=12 | [20,24], N=14 | [24,40], N=25 | |||
| 52 | 0.476 | ||||||
| Median [IQR] | 11.5 [7.8, 16.2] | 18.0 [14.5, 21.5] | 10.0 [9.0, 20.5] | 13.5 [7.2, 16.8] | 11.5 [7.0, 13.2] | ||
| Range | 1, 33 | 11, 25 | 5, 25 | 5, 33 | 1, 32 | ||
| 53 | |||||||
| Yes | 10 (18.9%) | 1 (50.0%) | 3 (25.0%) | 5 (35.7%) | 1 (4.0%) | ||
| No | 43 (81.1%) | 1 (50.0%) | 9 (75.0%) | 9 (64.3%) | 24 (96.0%) | ||
| 10 | 0.703 | ||||||
| Median [IQR] | 9.0 [6.2, 10.0] | 10.0 [10.0, 10.0] | 8.0 [7.5, 11.5] | 6.0 [4.0, 10.0] | 10.0 [10.0, 10.0] | ||
| Range | 2, 15 | 10, 10 | 7, 15 | 2, 13 | 10, 10 | ||
| 53 | 0.115 | ||||||
| Median [IQR] | 30.0 [15.0, 50.0] | 70.0 [65.0, 75.0] | 20.0 [10.0, 42.5] | 35.0 [15.0, 50.0] | 25.0 [10.0, 40.0] | ||
| Range | 0, 80 | 60, 80 | 5, 70 | 10, 60 | 0, 80 | ||
| 53 | 0.071 | ||||||
| Lack | 14 (26.4%) | 0 (0.0%) | 2 (16.7%) | 4 (28.6%) | 8 (32.0%) | ||
| Nasal canula | 18 (34.0%) | 0 (0.0%) | 8 (66.7%) | 4 (28.6%) | 6 (24.0%) | ||
| Simple oxygen mask | 5 (9.4%) | 1 (50.0%) | 0 (0.0%) | 1 (7.1%) | 3 (12.0%) | ||
| Non-rebreather mask | 15 (28.3%) | 0 (0.0%) | 2 (16.7%) | 5 (35.7%) | 8 (32.0%) | ||
| High-flow oxygen therapy | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | ||
| NIV | 1 (1.9%) | 1 (50.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | ||
| Respirator therapy | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | ||
| 53 | 0.099 | ||||||
| Lack | 7 (13.2%) | 0 (0.0%) | 0 (0.0%) | 2 (14.3%) | 5 (20.0%) | ||
| Nasal canula | 11 (20.8%) | 0 (0.0%) | 4 (33.3%) | 2 (14.3%) | 5 (20.0%) | ||
| Simple oxygen mask | 7 (13.2%) | 0 (0.0%) | 1 (8.3%) | 2 (14.3%) | 4 (16.0%) | ||
| Non-rebreather mask | 13 (24.5%) | 0 (0.0%) | 3 (25.0%) | 2 (14.3%) | 8 (32.0%) | ||
| High-flow oxygen therapy | 4 (7.5%) | 0 (0.0%) | 0 (0.0%) | 2 (14.3%) | 2 (8.0%) | ||
| NIV | 5 (9.4%) | 2 (100.0%) | 1 (8.3%) | 1 (7.1%) | 1 (4.0%) | ||
| Respirator therapy | 6 (11.3%) | 0 (0.0%) | 3 (25.0%) | 3 (21.4%) | 0 (0.0%) | ||
| 53 | 0.110 | ||||||
| No change | 16 (30.2%) | 1 (50.0%) | 1 (8.3%) | 3 (21.4%) | 11 (44.0%) | ||
| Worsening | 33 (62.3%) | 1 (50.0%) | 11 (91.7%) | 10 (71.4%) | 11 (44.0%) | ||
| Improvement | 4 (7.5%) | 0 (0.0%) | 0 (0.0%) | 1 (7.1%) | 3 (12.0%) | ||
| 53 | 2 | ||||||
| Yes | 9 (17.0%) | 1 (50.0%) | 3 (25.0%) | 4 (28.6%) | 1 (4.0%) | ||
| No | 44 (83.0%) | 1 (50.0%) | 9 (75.0%) | 10 (71.4%) | 24 (96.0%) | ||
| 1 Kruskal-Wallis rank sum test; Fisher’s exact test. 2 Due to a small 0–2-week group size, the credibility of formal testing is reduced; the change of the division of time from vaccination into categories should be considered. IQR – interquartile range; ICU – Intensive Care Unit; CT – computed tomography; NIV – non-invasive ventilation. | |||||||