Clinical Course of 53 Previously Vaccinated Patients Admitted to the National Hospital in Warsaw, Poland with COVID-19 Between November 2021 and March 2022

Artur Zaczyński; Michał Hampel; Paweł Piątkiewicz; Jacek Nasiłowski; Sławomir Butkiewicz; Urszula Religioni; Agnieszka Barańska; Maria Malm; Agnieszka Neumann-Podczaska; Regis Vaillancourt; Piotr Merks

doi:10.12659/MSM.939841

29 April 2023 : Database Analysis

Clinical Course of 53 Previously Vaccinated Patients Admitted to the National Hospital in Warsaw, Poland with COVID-19 Between November 2021 and March 2022

Artur Zaczyński^1AB, Michał Hampel^1AB, Paweł Piątkiewicz^2AB*, Jacek Nasiłowski^3AB, Sławomir Butkiewicz^2AB, Urszula Religioni^4DEF, Agnieszka Barańska^5CD, Maria Malm

^5CD, Agnieszka Neumann-Podczaska

^6DEF, Regis Vaillancourt^2ACDF, Piotr Merks^2AFG

DOI: 10.12659/MSM.939841

Med Sci Monit 2023; 29:e939841

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Table 4 Severity of the course Of COVID-19 vs time since vaccination.

Characteristic	N	Interval between the last dose and diagnose of COVID-19 [weeks]*					P value1
Characteristic	N	Overall, N=53	[0,2], N=2	[2,20], N=12	[20,24], N=14	[24,40], N=25	P value1
	52						0.476
Median [IQR]		11.5 [7.8, 16.2]	18.0 [14.5, 21.5]	10.0 [9.0, 20.5]	13.5 [7.2, 16.8]	11.5 [7.0, 13.2]
Range		1, 33	11, 25	5, 25	5, 33	1, 32
	53
Yes		10 (18.9%)	1 (50.0%)	3 (25.0%)	5 (35.7%)	1 (4.0%)
No		43 (81.1%)	1 (50.0%)	9 (75.0%)	9 (64.3%)	24 (96.0%)
	10						0.703
Median [IQR]		9.0 [6.2, 10.0]	10.0 [10.0, 10.0]	8.0 [7.5, 11.5]	6.0 [4.0, 10.0]	10.0 [10.0, 10.0]
Range		2, 15	10, 10	7, 15	2, 13	10, 10
	53						0.115
Median [IQR]		30.0 [15.0, 50.0]	70.0 [65.0, 75.0]	20.0 [10.0, 42.5]	35.0 [15.0, 50.0]	25.0 [10.0, 40.0]
Range		0, 80	60, 80	5, 70	10, 60	0, 80
	53						0.071
Lack		14 (26.4%)	0 (0.0%)	2 (16.7%)	4 (28.6%)	8 (32.0%)
Nasal canula		18 (34.0%)	0 (0.0%)	8 (66.7%)	4 (28.6%)	6 (24.0%)
Simple oxygen mask		5 (9.4%)	1 (50.0%)	0 (0.0%)	1 (7.1%)	3 (12.0%)
Non-rebreather mask		15 (28.3%)	0 (0.0%)	2 (16.7%)	5 (35.7%)	8 (32.0%)
High-flow oxygen therapy		0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)
NIV		1 (1.9%)	1 (50.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)
Respirator therapy		0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)	0 (0.0%)
	53						0.099
Lack		7 (13.2%)	0 (0.0%)	0 (0.0%)	2 (14.3%)	5 (20.0%)
Nasal canula		11 (20.8%)	0 (0.0%)	4 (33.3%)	2 (14.3%)	5 (20.0%)
Simple oxygen mask		7 (13.2%)	0 (0.0%)	1 (8.3%)	2 (14.3%)	4 (16.0%)
Non-rebreather mask		13 (24.5%)	0 (0.0%)	3 (25.0%)	2 (14.3%)	8 (32.0%)
High-flow oxygen therapy		4 (7.5%)	0 (0.0%)	0 (0.0%)	2 (14.3%)	2 (8.0%)
NIV		5 (9.4%)	2 (100.0%)	1 (8.3%)	1 (7.1%)	1 (4.0%)
Respirator therapy		6 (11.3%)	0 (0.0%)	3 (25.0%)	3 (21.4%)	0 (0.0%)
	53						0.110
No change		16 (30.2%)	1 (50.0%)	1 (8.3%)	3 (21.4%)	11 (44.0%)
Worsening		33 (62.3%)	1 (50.0%)	11 (91.7%)	10 (71.4%)	11 (44.0%)
Improvement		4 (7.5%)	0 (0.0%)	0 (0.0%)	1 (7.1%)	3 (12.0%)
	53						²
Yes		9 (17.0%)	1 (50.0%)	3 (25.0%)	4 (28.6%)	1 (4.0%)
No		44 (83.0%)	1 (50.0%)	9 (75.0%)	10 (71.4%)	24 (96.0%)
¹ Kruskal-Wallis rank sum test; Fisher’s exact test. ² Due to a small 0–2-week group size, the credibility of formal testing is reduced; the change of the division of time from vaccination into categories should be considered. IQR – interquartile range; ICU – Intensive Care Unit; CT – computed tomography; NIV – non-invasive ventilation.

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Clinical Course of 53 Previously Vaccinated Patients Admitted to the National Hospital in Warsaw, Poland with COVID-19 Between November 2021 and March 2022

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