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29 April 2023: Database Analysis

Clinical Course of 53 Previously Vaccinated Patients Admitted to the National Hospital in Warsaw, Poland with COVID-19 Between November 2021 and March 2022

Artur Zaczyński 1AB , Michał Hampel 1AB , Paweł Piątkiewicz 2AB* , Jacek Nasiłowski 3AB , Sławomir Butkiewicz 2AB , Urszula Religioni 4DEF , Agnieszka Barańska 5CD , Maria Malm 5CD , Agnieszka Neuman-Podczaska 6DEF , Regis Vaillancourt 2ACDF , Piotr Merks 2AFG

DOI: 10.12659/MSM.939841

Med Sci Monit 2023; 29:e939841

Table 4 Severity of the course Of COVID-19 vs time since vaccination.

CharacteristicNInterval between the last dose and diagnose of COVID-19 [weeks]*P value1
Overall, N=53[0,2], N=2[2,20], N=12[20,24], N=14[24,40], N=25
520.476
 Median [IQR]11.5 [7.8, 16.2]18.0 [14.5, 21.5]10.0 [9.0, 20.5]13.5 [7.2, 16.8]11.5 [7.0, 13.2]
 Range1, 3311, 255, 255, 331, 32
53
 Yes10 (18.9%)1 (50.0%)3 (25.0%)5 (35.7%)1 (4.0%)
 No43 (81.1%)1 (50.0%)9 (75.0%)9 (64.3%)24 (96.0%)
100.703
 Median [IQR]9.0 [6.2, 10.0]10.0 [10.0, 10.0]8.0 [7.5, 11.5]6.0 [4.0, 10.0]10.0 [10.0, 10.0]
 Range2, 1510, 107, 152, 1310, 10
530.115
 Median [IQR]30.0 [15.0, 50.0]70.0 [65.0, 75.0]20.0 [10.0, 42.5]35.0 [15.0, 50.0]25.0 [10.0, 40.0]
 Range0, 8060, 805, 7010, 600, 80
530.071
 Lack14 (26.4%)0 (0.0%)2 (16.7%)4 (28.6%)8 (32.0%)
 Nasal canula18 (34.0%)0 (0.0%)8 (66.7%)4 (28.6%)6 (24.0%)
 Simple oxygen mask5 (9.4%)1 (50.0%)0 (0.0%)1 (7.1%)3 (12.0%)
 Non-rebreather mask15 (28.3%)0 (0.0%)2 (16.7%)5 (35.7%)8 (32.0%)
 High-flow oxygen therapy0 (0.0%)0 (0.0%)0 (0.0%)0 (0.0%)0 (0.0%)
 NIV1 (1.9%)1 (50.0%)0 (0.0%)0 (0.0%)0 (0.0%)
 Respirator therapy0 (0.0%)0 (0.0%)0 (0.0%)0 (0.0%)0 (0.0%)
530.099
 Lack7 (13.2%)0 (0.0%)0 (0.0%)2 (14.3%)5 (20.0%)
 Nasal canula11 (20.8%)0 (0.0%)4 (33.3%)2 (14.3%)5 (20.0%)
 Simple oxygen mask7 (13.2%)0 (0.0%)1 (8.3%)2 (14.3%)4 (16.0%)
 Non-rebreather mask13 (24.5%)0 (0.0%)3 (25.0%)2 (14.3%)8 (32.0%)
 High-flow oxygen therapy4 (7.5%)0 (0.0%)0 (0.0%)2 (14.3%)2 (8.0%)
 NIV5 (9.4%)2 (100.0%)1 (8.3%)1 (7.1%)1 (4.0%)
 Respirator therapy6 (11.3%)0 (0.0%)3 (25.0%)3 (21.4%)0 (0.0%)
530.110
 No change16 (30.2%)1 (50.0%)1 (8.3%)3 (21.4%)11 (44.0%)
 Worsening33 (62.3%)1 (50.0%)11 (91.7%)10 (71.4%)11 (44.0%)
 Improvement4 (7.5%)0 (0.0%)0 (0.0%)1 (7.1%)3 (12.0%)
532
 Yes9 (17.0%)1 (50.0%)3 (25.0%)4 (28.6%)1 (4.0%)
 No44 (83.0%)1 (50.0%)9 (75.0%)10 (71.4%)24 (96.0%)
1 Kruskal-Wallis rank sum test; Fisher’s exact test.
2 Due to a small 0–2-week group size, the credibility of formal testing is reduced; the change of the division of time from vaccination into categories should be considered.
IQR – interquartile range; ICU – Intensive Care Unit; CT – computed tomography; NIV – non-invasive ventilation.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750