Telomere-Associated Gene Signatures Correlate with Prognosis, Tumor Microenvironment, and Chemosensitivity in Breast Cancer

28 June 2023 : Database Analysis

Yuanyuan Hu^1ABCDEF, Xiongbin You^2ABCD, Ziwei Zhang^2ABCDF, Hong Zhao^1E*

DOI: 10.12659/MSM.939921

Med Sci Monit 2023; 29:e939921

Background Material and Methods Results Discussion Conclusions References

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Table 1 The univariate and multivariate Cox regression analysis of risk score and clinicopathological features.

	p-value	HR	95% CI		p-value	HR	95% CI
	p-value	HR	Lower	Upper	p-value	HR	Lower	Upper
Riskscore	<0.001	2.717	2.102	3.513	<0.001	2.282	1.754	2.969
Race (Asian as ref.)	0.8
Black	0.341	2.657	0.355	19.906
Other	0.325	3.016	0.335	27.186
White	0.344	2.595	0.36	18.698
Age	0.014	1.642	1.107	2.435
Radiotherapy	<0.001	0.217	0.135	0.347	<0.001	0.253	0.154	0.416
Chemotherapy	<0.001	0.275	0.159	0.474
Stage (I as ref.)	<0.001
II	0.439	1.318	0.656	2.649
III	0.003	2.832	1.413	5.675
IV	<0.001	6.734	2.832	16.014
X	0.166	1.601	0.823	3.115
T stage (T1 as ref.)	0.136
T2	0.697	1.102	0.676	1.797
T3	0.448	1.279	0.678	2.413
T4	0.016	2.489	1.181	5.242
TX	0.577	0.565	0.076	4.211
N stage (N0 as ref.)	<0.001				<0.001
N1	0.007	1.949	1.195	3.176	0.152	1.433	0.876	2.344
N2	<0.001	3.21	1.703	6.05	<0.001	3.399	1.796	6.43
N3	<0.001	5.428	2.6	11.333	<0.001	6.418	3.054	13.488
NX	<0.001	5.337	2.412	11.807	0.015	2.735	1.215	6.156
M stage (M0 as ref.)	0.019
M1	0.005	2.689	1.348	5.365
MX	0.913	1.044	0.481	2.269

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