Telomere-Associated Gene Signatures Correlate with Prognosis, Tumor Microenvironment, and Chemosensitivity in Breast Cancer

28 June 2023: Database Analysis

Yuanyuan Hu ^1ABCDEF , Xiongbin You ^2ABCD , Ziwei Zhang ^2ABCDF , Hong Zhao ^1E*

DOI: 10.12659/MSM.939921

Med Sci Monit 2023; 29:e939921

Table 1 The univariate and multivariate Cox regression analysis of risk score and clinicopathological features.

	p-value	HR	95% CI		p-value	HR	95% CI
	p-value	HR	Lower	Upper	p-value	HR	Lower	Upper
Riskscore		2.717	2.102	3.513		2.282	1.754	2.969
Race (Asian as ref.)	0.8
Black	0.341	2.657	0.355	19.906
Other	0.325	3.016	0.335	27.186
White	0.344	2.595	0.36	18.698
Age	0.014	1.642	1.107	2.435
Radiotherapy		0.217	0.135	0.347		0.253	0.154	0.416
Chemotherapy		0.275	0.159	0.474
Stage (I as ref.)
II	0.439	1.318	0.656	2.649
III	0.003	2.832	1.413	5.675
IV		6.734	2.832	16.014
X	0.166	1.601	0.823	3.115
T stage (T1 as ref.)	0.136
T2	0.697	1.102	0.676	1.797
T3	0.448	1.279	0.678	2.413
T4	0.016	2.489	1.181	5.242
TX	0.577	0.565	0.076	4.211
N stage (N0 as ref.)
N1	0.007	1.949	1.195	3.176	0.152	1.433	0.876	2.344
N2		3.21	1.703	6.05		3.399	1.796	6.43
N3		5.428	2.6	11.333		6.418	3.054	13.488
NX		5.337	2.412	11.807	0.015	2.735	1.215	6.156
M stage (M0 as ref.)	0.019
M1	0.005	2.689	1.348	5.365
MX	0.913	1.044	0.481	2.269