22 August 2023: Clinical Research
Comparative Analysis of Laparoscopic Pancreatoduodenectomy in Elderly Patients: Safety, Efficacy, and Cost Evaluation
Chengfang Wang ABCDEF* , Zhijiang Wang ABDF* , Weilin Wang ADFG*DOI: 10.12659/MSM.940176
Med Sci Monit 2023; 29:e940176
Table 2 Perioperative outcomes of patients.
| Group A (n=100) | Group B (n=60) | Group C (n=90) | P1 value | P2 value | |
|---|---|---|---|---|---|
| Conversion (n, %) | 19 (19.0) | 21 (35.0) | – | 0.037 | – |
| Operative time (min) | 445.0 (380–515) | 462.50 (402.50–493.75) | 315 (270.0–367.5) | 0.974 | |
| Intraoperative transfusion (n, %) | 35 (35.0) | 30 (50.0) | 40 (44.44) | 0.069 | 0.510 |
| EBL (ml) | 200 (100–300) | 200 (100–400) | 200 (200–400) | 0.845 | 0.026 |
| Vascular reconstruction (n, %) | 3 (3.00) | 7 (11.67) | 16 (17.78) | 0.041 | 0.361 |
| Postoperative ICU admission (n, %) | 23 (23.00) | 27 (45.00) | 39 (43.33) | 0.005 | 0.868 |
| Postoperative ICU stay (days) | 0 (0–0) | 0 (0–2) | 0 (0–1.25) | 0.001 | 0.819 |
| POHS (days) | 16 (13–24) | 18 (14–22) | 19 (14–28) | 0.165 | 0.481 |
| reoperation (n, %) | 7 (7.00) | 4 (6.67) | 10 (11.11) | 1.000 | 0.407 |
| Postoperative infection (n, %) | 42 (42.0) | 26 (43.33) | 44 (48.89) | 0.871 | 0.616 |
| Biliary fistula (n, %) | 4 (4.0) | 6 (10.0) | 3 (3.33) | 0.178 | 0.157 |
| POPF (n,%) | 0.007 | 0.459 | |||
| Grade B | 21 (21.0) | 2 (3.33) | 2 (2.22) | ||
| Grade C | 3 (3.0) | 1 (1.67) | 5 (5.56) | ||
| PPH (n, %) | 10 (10.0) | 4 (6.67) | 9 (10.0) | 0.572 | 0.564 |
| Wound infection (n, %) | 5 (5.0) | 2 (3.33) | 16 (17.78) | 0.712 | 0.009 |
| B/C DGE (n, %) | 12 (12.0) | 10 (17.54) | 26 (31.33) | 0.348 | 0.078 |
| Time to oral intake (days) | 5 (3–6) | 5.5 (4–7) | 5 (2.25–6.00) | 0.071 | 0.041 |
| Chyle fistula (n, %) | 23 (23.0) | 18 (30.0) | 22 (24.44) | 0.353 | 0.458 |
| Postoperative drainage (n, %) | 32 (32.0) | 15 (25.0) | 21 (23.33) | 0.375 | 0.847 |
| Discharged with a drainage tube (n, %) | 54 (54.0) | 27 (45.0) | 32 (35.56) | 0.328 | 0.306 |
| Postoperative liver dysfunction (n, %) | 8 (8.00) | 4 (6.67) | 9 (10.00) | 1.000 | 0.564 |
| Postoperative renal dysfunction (n, %) | 5 (5.00) | 5 (8.33) | 14 (15.56) | 0.504 | 0.220 |
| Clavien-Dindo classification ≥III (n, %) | 33 (33.00) | 19 (31.67) | 29 (32.22) | 1.000 | 1.000 |
| 30-day readmission (n, %) | 10 (10.0) | 2 (3.33) | 5 (5.56) | 0.400 | 1.000 |
| 90-day mortality (n, %) | 3 (3.0) | 3 (5.0) | 6 (6.67) | 0.673 | 0.742 |
| Hospitalization expenses | 106698.38 (95287.13–131206.46) | 118782.48 (102963.99–144557.36) | 111541.60 (80051.98–135305.85) | 0.036 | 0.037 |
| Adjuvant therapy (n, %) | 54 (69.23) | 15 (31.91) | 33 (40.24) | 0.449 | |
| Time to start adjuvant therapy (days) | 52 (36.25–68.5) | 57 (47–70) | 55 (46–65.5) | 0.443 | 0.548 |
| P1: Group A vs Group B, P2: Group B vs Group C. EBL – estimated blood loss; POHS – postoperative hospital stay; POPF – postoperative pancreatic fistula; DGE – delayed gastric emptying; PPH – post pancreatectomy hemorrhage. | |||||