15 June 2023>: Clinical Research
Risk Prediction for Rapidly Progressive Interstitial Lung Disease in Anti-MDA5-Positive Dermatomyositis: The CRAFT Model
Jinqiang Guo 1ABCDEF* , Chunli Mei 1ABCEF* , Qi Yu 2BCD , Anbin Huang 1AEF*DOI: 10.12659/MSM.940251
Med Sci Monit 2023; 29:e940251
Table 1 The baseline demographic and clinical characteristics of patients with MDA5+ DM (n=53).
Characteristic | Non-RP-ILD Group (n=32) | RP-ILD Group (n=21) | Statistical methods | P value |
---|---|---|---|---|
Age, years, median (range) | 50 (42–57) | 57 (52–63) | Mann-Whitney U test | 0.011 |
Sex, n (%) | ||||
Female | 21 (66) | 13 (62) | ||
Male | 11 (34) | 8 (38) | Chi-squared test | 0.78 |
ILD, n (%) | 28 (86) | 21 (100) | Fisher’s exact test | 1 |
CADM, n (%) | 10 (31) | 10 (48) | Chi-squared test | 0.23 |
Anti-MDA5 titer, n (%) | ||||
+ | 11 (34) | 2 (10) | ||
++ | 4 (13) | 7 (33) | ||
+++ | 17 (53) | 12 (57) | Chi-squared test | 0.32 |
Clinical features, n (%) | ||||
Heliotrope rash | 14 (44) | 12 (57) | Chi-squared test | 0.34 |
Gottron’s sign/papules | 25 (78) | 15 (71) | Chi-squared test | 0.58 |
Erythematous facial rash | 24 (75) | 9 (43) | Chi-squared test | 0.018 |
Periungual erythema | 5 (06) | 8 (38) | Chi-squared test | 0.063 |
Mechanic’s hands | 2 (6) | 6 (29) | Fisher’s exact test | 0.047 |
V sign | 11 (34) | 5 (24) | Chi-squared test | 0.41 |
Shawl Sign | 1 (3) | 5 (24) | Chi-squared test | 0.41 |
Skin ulcers | 11 (34) | 3 (14) | Chi-squared test | 0.105 |
Pruritus | 4 (13) | 4 (19) | Fisher’s exact test | 0.70 |
Dry mouth | 5 (16) | 4 (19) | Fisher’s exact test | 1 |
Oral ulcer | 5 (16) | 3 (14) | Fisher’s exact test | 1 |
Raynaud’s phenomenon | 7 (22) | 2 (10) | Fisher’s exact test | 0.29 |
Arthritis | 25 (78) | 13 (62) | Chi-square test | 0.2 |
Morning stiffness | 6 (19) | 4 (19) | Fisher’s exact test | 1 |
Myalgia | 13 (41) | 6 (29) | Chi-squared test | 0.37 |
Proximal weakness | 22 (69) | 11 (52) | Chi-squared test | 0.23 |
Fever | 4 (13) | 13 (62) | Chi-squared test | |
Dysphagia | 2 (6) | 3 (14) | Fisher’s exact test | 0.37 |
Alopecia | 8 (25) | 1 (5) | Fisher’s exact test | 0.071 |
Weight loss | 1 (3) | 2 (10) | Fisher’s exact test | 0.56 |
MDA5 – anti-melanoma differentiation-associated gene 5; RP-ILD – rapidly progressive interstitial lung disease; ILD – interstitial lung disease; CADM – clinically amyopathic dermatomyositis. |