08 December 2023: Clinical Research
Efficacy Analysis of Neoadjuvant versus Adjuvant Cisplatin-Paclitaxel Regimens for Initial Treatment of FIGO Stages IB3 and IIA2 Cervical Cancer
Wei Tao 1DEF* , Weiqi Wang 1CDF , Jingfang Zhai 2BCF , Linlin Guo 1ABFDOI: 10.12659/MSM.940545
Med Sci Monit 2023; 29:e940545
Table 3 Demographic and clinical characteristics of patients before chemoradiotherapies in the NT cohort.
| Characteristics | NT cohort | ||||||
|---|---|---|---|---|---|---|---|
| Sensitive to neoadjuvant chemotherapy | Insensitive to neoadjuvant chemotherapy | Comparisons | |||||
| Number of patients | 80 | 25 | P value | df | Test value | 95% CI | |
| Age (years) | 39.98±1.02 | 48.8±1.75 | 103 | 4.731 | 5.707 to 13.943 | ||
| Hemoglobin (g/dL) | 10.13±0.06 | 9.68±0.16 | 0.0128 (Unpaired test with Welch correction) | 30 | 2.649 | −0.7832 to −0.1013 | |
| Platelet (×10)/L | 285±19 | 418±24 | 55 | 4.301 | 70.490 to 193.47 | ||
| Body mass index (kg/m) | 24.53±0.15 | 22.9±0.29 | 103 | 4.88 | −2.173 to −0.9170 | ||
| Tumor size (cm) | 4.48±0.26 | 7.92±0.17 | 100 | 11.095 | 2.829 to 4.061 | ||
| FIGO stage | IB3 | 55 (69) | 5 (20) | N/A | 1.65 | 1.257 to 2.166 | |
| IIA2 | 25 (31) | 20 (80) | |||||
| Parameters are depicted as frequencies (percentages) or mean±standard error of the mean (SEM). All results were considered significant if the value was less than 0.05. Sensitivity to neoadjuvant chemotherapy: complete response (absence of tumor cells and lymph nodes in pathology)+partial response (≥30 % decrease in the sum of the longest diameter of tumor). Insensitivity to neoadjuvant chemotherapy: progressive disease (≥20 % increase in the sum of longest diameters with an absolute increase of ≥5 mm, or detection of new lesions)+stable disease (neither partial response nor progressive disease). RECIST v1.1 was used to evaluate the response. N/A – not applicable; df – degree of freedom; CI – confidence interval (using the approximation of Katz for Fisher exact test). Test value (t value for Unpaired test, Welch’s approximate t value for unpaired test with Welch correction, relative risk for Fisher exact test). | |||||||