08 December 2023: Clinical Research
Efficacy Analysis of Neoadjuvant versus Adjuvant Cisplatin-Paclitaxel Regimens for Initial Treatment of FIGO Stages IB3 and IIA2 Cervical Cancer
Wei Tao 1DEF* , Weiqi Wang 1CDF , Jingfang Zhai 2BCF , Linlin Guo 1ABFDOI: 10.12659/MSM.940545
Med Sci Monit 2023; 29:e940545
Table 4 Operative parameters of patients in the NT cohort.
| Characteristics | NT cohort | Comparisons | |||||
|---|---|---|---|---|---|---|---|
| Sensitive to neoadjuvant chemotherapy | Insensitive to neoadjuvant chemotherapy | ||||||
| Number of patients | 80 | 25 | P value | df | Test value | 95% CI | |
| Nature of radical hysterectomy | Robot-assisted radical hysterectomy | 45 (56) | 8 (32) | 0.0105 (χ test for independence) | 2 | 9.112 | N/A |
| Laparoscopic radical hysterectomy | 32 (40) | 12 (48) | |||||
| Abdominal radical hysterectomy (open surgery) | 3 (4) | 5 (20) | |||||
| Intraoperative hemorrhage (mL) | 421±26 | 539±54 | 0.0344 (Unpaired test) | 103 | 2.144 | 8.790 to 225.69 | |
| Parametrium excision (cm) | 3.53±0.09 | 4.03±0.16 | 0.0093 (Unpaired -test) | 103 | 2.653 | 0.1225 to 0.8485 | |
| Postoperative complications | |||||||
| Injury to the urinary system | 0 (0) | 2 (8) | 0.0549 (Fisher exact test) | N/A | 0 | −Infinity to Infinity | |
| Gastrointestinal tract | 0 (0) | 5 (20)* | 0.0006 (Fisher exact test) | N/A | 0 | −Infinity to Infinity | |
| Injuries of vessels | 0 (0) | 1 (4) | 0.2381 (Fisher exact test) | N/A | 0 | −Infinity to Infinity | |
| Infection | 1 (1) | 6 (24)* | 0.0006 (Fisher exact test) | N/A | 0.1772 | 0.02878 to 1.091 | |
| Lymphocyst | 10 (13) | 1 (4) | 0.4532 (Fisher exact test) | N/A | 1.221 | 0.9785 to 1.523 | |
| Thrombosis | 0 (0) | 2 (8) | 0.0549 (Fisher exact test) | N/A | 0 | −Infinity to Infinity | |
| Catheter time (days) | 10.11±0.61 | 13.84±1.2* | 0.0046 (Unpaired test) | 103 | 2.898 | 1.177 to 6.278 | |
| Postoperative drainage (mL) | 2,318±145 | 4,058±447* | 0.0009 (Unpaired test with Welch correction) | 29 | 3.7 | 778.04 to 2701.3 | |
| Parameters are depicted as frequencies (percentages) or mean±standard error of the mean (SEM). All results were considered significant if the value was less than 0.05. * Insensitive to neoadjuvant chemotherapy-emergent postoperative complications. df – degree of freedom; N/A – not applicable; CI – confidence interval (using the approximation of Katz for χ-test). Test value (χ value for χ test, t value for unpaired test, Welch’s approximate t value for unpaired test with Welch correction, relative risk for Fisher exact test). | |||||||