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16 September 2023: Review Articles

A Review of the Role of Tendon Stem Cells in Tendon-Bone Regeneration

Junjie Chen 1EFG* , Chuanfeng Jiang 1EF* , Lu Yin 1EF* , Yingqi Liu 2EF , Yue He 3EF , Sen Li 4EF* , Huarui Shen 1FG*

DOI: 10.12659/MSM.940805

Med Sci Monit 2023; 29:e940805

Table 1 Current tendon stem cell (TDSC) research.

Stem celltTypeAnimalOutcomeConclusionAuthorReferences
Tendon cells/TDSCsMiceTDSCs had a round appearance compared to fibroblastsDifferences in morphology, clonogenicity, stem cell marker expression and multipotency observed between tenocytes and TDSCs indicate that at least two cell populations are present in murine tail tendonLee[]10
TDSCsHorseThere are three different types of differentiation in the stem cell lines. Tendons, bone, and fat are some of the different phenotypesIsolation of TDSCs lines with the ability to differentiate into all four connective tissue lineages may yield better therapeutic benefits. Future studies may aim to understand the functional contribution of each TDSCs phenotype in the bodyRajpar[]12
Equine stem cellsHorseThere may be a risk of ectopic bone formation after cell injectionThis review provides an overview of current strategies for stem cell therapy for equine tendon injuryShojaee[]13
Human TDSCs of the supraspinatus and biceps longheadHumanCells exhibit adult stem cell characteristics (ie, they are self-renewing in vitro, clotogenic, and pluripotent) They can be induced to differentiate into different cell types – ie, osteoblasts, adipocytes, and skeletal muscle cellsHuman rotator cuff TDSCs and human biceps tendon longhead stem cells can be isolated and have a high regenerative potential. Sphingolipid patterns of isolated cells vs those of BMSCs and fibroblasts reveals the possibility of using such lipids as possible markers of cell differentiation statusRandelli[]14

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750