01 August 2023 : Database Analysis
Impact of Pre-Transplant Parathyroidectomy on Graft Survival: A Comparative Study of Renal Transplant Patients (2005-2015)
Ming-Hsien Tsai12ADEF, Mingchih Chen
34ABD, Hung-Hsiang Liou5AD, Tian-Shyug Lee34B, Yen-Chun Huang34C, Pei-Yang Liu6F, Yu-Wei Fang 72AEFG*
DOI: 10.12659/MSM.940959
Med Sci Monit 2023; 29:e940959
Table 2 Comparison of outcomes between those with/without parathyroidectomy prior kidney transplantation.
| Clinical outcomes | After matching | |||||||
|---|---|---|---|---|---|---|---|---|
| PTx before KT (n=294) | Non-PTx before KT (n=588) | Crude HR (95% CI) | p value | aHR* (95% CI) | p value | |||
| Events | IR (1000 PYs) | Events | IR (1000 PYs) | |||||
| Graft failure | 60 | 33 | 77 | 22 | 1.40 (1.10–1.79) | 0.007 | 1.52 (1.07–2.15) | 0.019 |
| All-cause mortality | 58 | 27 | 122 | 31 | 0.90 (0.69–1.16) | 0.409 | 0.88 (0.63–1.21) | 0.419 |
| MACE | 34 | 17 | 56 | 15 | 0.97 (0.70–1.33) | 0.835 | 1.15 (0.74–1.79) | 0.536 |
| Stroke | 72 | 34 | 117 | 31 | 1.21 (0.85–1.73) | 0.297 | 1.13 (0.71–1.81) | 0.616 |
| Fracture | 14 | 7 | 16 | 4 | 0.84 (0.49–1.43) | 0.512 | 1.91 (0.91–4.03) | 0.088 |
| * Additional variables were adjusted for, including myocardial infarction, chronic obstructive pulmonary disease, kidney transplant with complications, Charlson comorbidity index score, calcium channel blockers, insulin, and oral hypoglycemic agents, which showed significant differences between the groups with and without PTx in . PTx – parathyroidectomy; KT – kidney transplant; IR – incidence rate; PY – per person-year; MACE – major adverse cardiac event. | ||||||||