27 October 2023 : Clinical Research
The Impact of Sedentary Behavior on Renal Function Decline in 132,123 Middle Aged and Older Adults: A Nationwide Cohort Study
Peng Yu12ABCDEF, Zhiyun Zhao34BC, Li Huang12B, Huajie Zou12B, Xiaoyu Meng12B, Ranran Kan12F, Xuefeng Yu12ABDG*DOI: 10.12659/MSM.941111
Med Sci Monit 2023; 29:e941111
Table 1 Baseline characteristics of the study participants according to quartiles of sitting time.
| Full cohort | Quartile 1 (n=32947) | Quartile 2 (n=27162) | Quartile 3 (n=37810) | Quartile 4 (n=34204) | P value | |
|---|---|---|---|---|---|---|
| Age, years | 56.64±9.01 | 57.25±8.98 | 57.02±8.86 | 56.92±8.89 | 55.44±9.18 | <0.001 |
| Female (%) | 86321 (65.3) | 21552 (65.4) | 17937 (66.0) | 25088 (66.4) | 21744 (63.6) | <0.001 |
| Current smoking (%) | 19940 (15.4) | 4541 (13.8) | 3886 (14.3) | 5584 (14.8) | 5929 (17.3) | <0.001 |
| Current drinking (%) | 13988 (10.9) | 3723 (11.3) | 2787 (10.3) | 3758 (9.9) | 3720 (10.9) | <0.001 |
| MVPA (hour/week) | 1.40±4.98 | 1.62±6.29 | 1.30±4.70 | 1.38±4.46 | 1.28±4.28 | <0.001 |
| BMI (kg/m) | 24.64±3.61 | 24.51±3.71 | 24.65±3.55 | 24.70±3.55 | 24.70±3.65 | <0.001 |
| WC (cm) | 84.01±9.83 | 83.44±9.93 | 83.83±9.85 | 84.31±9.77 | 83.37±9.77 | <0.001 |
| SBP (mmHg) | 133.2±20.76 | 135.60±21.48 | 134.29±20.77 | 132.85±20.39 | 130.27±20.08 | <0.001 |
| DBP (mmHg) | 78.51±11.14 | 78.85±11.27 | 78.58±11.14 | 78.50±11.03 | 78.13±11.12 | <0.001 |
| FPG (mmol/L) | 5.95±1.61 | 5.94±1.59 | 5.95±1.60 | 5.98±1.63 | 5.94±1.62 | 0.003 |
| 2hPG (mmol/L) | 8.24±3.82 | 8.10±3.81 | 8.24±3.85 | 8.34±3.84 | 8.25±3.76 | <0.001 |
| HbA1c (%) | 6.01±1.01 | 6.00±1.01 | 6.00±1.00 | 6.02±1.02 | 6.00±1.01 | 0.154 |
| TC (mmol/L) | 4.96±1.14 | 4.93±1.13 | 4.99±1.13 | 4.99±1.13 | 4.92±1.16 | <0.001 |
| TG (mmol/L) | 1.32 (0.93–1.91) | 1.25 (0.89–1.82) | 1.30 (0.92–1.90) | 1.34 (0.96–1.94) | 1.37 (0.96–1.99) | <0.001 |
| HDL-C (mmol/L) | 1.34±0.36 | 1.37±0.37 | 1.35±0.37 | 1.33±0.36 | 1.30±0.35 | <0.001 |
| LDL-C (mmol/L) | 2.88±0.88 | 2.84±0.87 | 2.89±0.87 | 2.91±0.88 | 2.87±0.89 | <0.001 |
| Cr (μmol/L) | 65.73±12.15 | 64.54±11.60 | 65.59±11.91 | 66.05±12.17 | 66.63±12.72 | <0.001 |
| eGFR (mL/min/1.73 m) | 95.23±11.90 | 95.91±11.45 | 95.02±11.70 | 94.58±11.94 | 95.48±12.38 | <0.001 |
| Prevalence of hypertension (%) | 59174 (44.8) | 15639 (47.5) | 12501 (46.0) | 17098 (45.2) | 13936 (40.7) | <0.001 |
| Prevalence of diabetes (%) | 30689 (23.2) | 7444 (22.6) | 6318 (23.3) | 9036 (23.9) | 7891 (23.1) | <0.001 |
| Prevalence of dyslipidemia (%) | 56346 (42.7) | 12879 (39.1) | 11360 (41.8) | 16470 (43.6) | 15637 (45.7) | <0.001 |
| Continuous variables are expressed as the mean (standard deviation) or median (IQR), and categorical variables are expressed as the number (percentage). Quartiles of sitting time: 1 quartile ≤17.4 h/week, 2 quartile=17.5–27.9 h/week, 3 quartile=28.0–36.9 h/week, 4 quartile ≥37 h/week. eGFR – estimated glomerular filtration rate; MVPA – moderate or vigorous intensity physical activity; BMI – body mass index; WC – waist circumference; SBP – systolic blood pressure; DBP – diastolic blood pressure; FPG – fasting blood glucose; 2hPG – 2 hours postprandial blood glucose; TG – triglycerides; TC – total cholesterol; HDL-C – high-density lipoprotein cholesterol; LDL-C – low-density lipoprotein cholesterol; Cr – creatinine. | ||||||