27 October 2023: Clinical Research
The Impact of Sedentary Behavior on Renal Function Decline in 132,123 Middle Aged and Older Adults: A Nationwide Cohort Study
Peng Yu 12ABCDEF , Zhiyun Zhao 34BC , Li Huang 12B , Huajie Zou 12B , Xiaoyu Meng 12B , Ranran Kan 12F , Xuefeng Yu 12ABDG*DOI: 10.12659/MSM.941111
Med Sci Monit 2023; 29:e941111
Supplementary Table 5 Sensitivity analysis of associations between sitting time and kidney function decline-4 (n=132 123).
| Quartile 1 (n=32 947) | Quartile 2 (n=27 162) | Quartile 3 (n=37 810) | Quartile 4 (n=34 204) | P for trend | |
|---|---|---|---|---|---|
| Cases | 624 (1.9%) | 507 (1.9%) | 739 (2.0%) | 736 (2.2%) | 0.013 |
| Model 1 | 1 | 0.960 (0.854–1.079) | 0.990 (0.890–1.102) | 1.033 (0.928–1.149) | 0.465 |
| Model 2 | 1 | 0.957 (0.849–1.079) | 1.001 (0.898–1.115) | 1.099 (0.986–1.226) | 0.062 |
| Model 3 | 1 | 0.948 (0.838–1.072) | 0.994 (0.889–1.111) | 1.078 (0.964–1.205) | 0.126 |
| The outcome was defined as more than a 30% decrease in eGFR from baseline, CKD-related hospitalization or death, or the presence of end-stage renal disease. Quartiles of sitting time: 1 quartile ≤17.4 h/week, 2 quartile=17.5–27.9 h/week, 3 quartile=28.0–36.9 h/week, 4 quartile ≥37 h/week. Crude HR. Adjusted for age, sex, current smoking, and current drinking. Adjusted for covariates in Model 2 plus BMI, hypertension, diabetes, dyslipidaemia and MVPA. HR – hazard ratio; CI – confidence interval. | |||||