25 September 2023 : Clinical Research
Impact of Nonselective and Selective α-1 Adrenergic Blockers on the Sedative Efficacy of Dexmedetomidine in Urologic Surgery: A Prospective, Observational Study
Jiseok Baik
12DEF, Ohyun Kim 1B, Soeun Jeon 3C, Hyae Jin Kim 12BE, Boo-young Hwang 12BD, Dowon Lee 12ADEF*
DOI: 10.12659/MSM.941614
Med Sci Monit 2023; 29:e941614
Table 2 Demographic data, medication, and patient characteristics.
| Group N (n=33) | Group NS (n=27) | Group S (n=58) | p-value | |
|---|---|---|---|---|
| ASA class | 1.000 | |||
| I | 5 | 4 | 8 | |
| II | 28 | 23 | 50 | |
| Age (yr) | 64.2 (7.9) | 66.7 (7.7) | 67.2 (7.9) | 0.170 |
| Height (cm) | 167.6 (6.7) | 167.9 (4.9) | 167.0 (4.4) | 0.741 |
| Weight (kg) | 69.3 (9.7) | 64.7 (8.1) | 67.7 (8.3) | 0.128 |
| Drug name (%) | ||||
| Alfuzosin | 7 (25.9) | |||
| Doxazosin | 6 (22.2) | |||
| Terazosin | 14 (51.9) | |||
| Silodosin | 25 (43.1) | |||
| Tamsulosin | 33 (56.9) | |||
| Duration of medication (month) | 24.0 (9.0, 60.0) | 33.0 (11.0, 50.0) | 0.726 | |
| Type of surgery (%) | 0.167 | |||
| HOLEP or TUR-P | 33 (100.0) | 24 (88.9) | 54 (93.1) | |
| TUR-BT | 0 (0.0) | 3 (11.1) | 2 (3.4) | |
| Others | 0 (0.0) | 2 (3.4) | ||
| Data are presented as the mean (SD) or number of patients. SD – standard deviation; Group N – no medication group; Group NS – nonselective α−1 blocker medication group; Group S – selective α−1 blocker medication group; ASA class – American Society of Anesthesiologists physical status class; HOLEP – holmium laser enucleation of the prostate; TUR-P – transurethral resection of the prostate; TUR-BT – transurethral resection of the bladder tumor. | ||||