Enhanced Proliferation and Adhesion Marker Gene Expression in Fibroblast Cells: Evaluating the Efficacy of a Non-Surgical Treatment for Urogenital Fistula

Efriyan Imantika; R.M. Sonny Sasotya; Edwin Armawan; Kevin D. Tjandraprawira; Rodiani Rodiani; Taufiqurrahman Rahim

doi:10.12659/MSM.941641

18 November 2023 : Laboratory Research

Enhanced Proliferation and Adhesion Marker Gene Expression in Fibroblast Cells: Evaluating the Efficacy of a Non-Surgical Treatment for Urogenital Fistula

Efriyan Imantika

^12ABCDEF*, R.M. Sonny Sasotya^1ADEF, Edwin Armawan^1ACDEF, Kevin D. Tjandraprawira^1DEF, Rodiani Rodiani^2AEF, Taufiqurrahman Rahim^2AEF

DOI: 10.12659/MSM.941641

Med Sci Monit 2023; 29:e941641

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Table 3 Tukey’s Post Hoc Analysis of TGF-β, JAMs, and LOX expression in fibroblast cells treated with mucoadhesive bilayer membrane combined with ALSR, estrogen, or arginine+glutamine.

Gene expression	Mean difference	95% CI		p

		Min	Max


1 vs 2	55.4	22.2	88.6	0.003^*
1 vs 3	0.6	−32.5	33.8	0.9
1 vs 4	61.6	28.4	94.8	0.002^*
2 vs 3	54.7	21.6	87.9	0.003^*
2 vs 4	6.2	−26.9	39.4	0.9
3 vs 4	61	27.8	94.2	0.002^*


1 vs 2	10.6	−13.7	35	0.53
1 vs 3	28.5	4.08	52.8	0.02^*
1 vs 4	12.3	12	36.7	0.42
2 vs 3	39.1	14.7	63.5	0.004^*
2 vs 4	1.7	−22.7	26.1	0.9
3 vs 4	40.8	16.4	65.2	0.003^*
TGF-β – tumor growth factor beta; JAMs – junctional adhesion molecules; LOX – lysil oxidase; ALSR – lyophilized radiation-sterilized amnion. – 5 day; – 10 day; ^*

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Enhanced Proliferation and Adhesion Marker Gene Expression in Fibroblast Cells: Evaluating the Efficacy of a Non-Surgical Treatment for Urogenital Fistula

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