Enhanced Proliferation and Adhesion Marker Gene Expression in Fibroblast Cells: Evaluating the Efficacy of a Non-Surgical Treatment for Urogenital Fistula

Efriyan Imantika; R.M. Sonny Sasotya; Edwin Armawan; Kevin D. Tjandraprawira; Rodiani Rodiani; Taufiqurrahman Rahim

doi:10.12659/MSM.941641

18 November 2023 : Laboratory Research

Enhanced Proliferation and Adhesion Marker Gene Expression in Fibroblast Cells: Evaluating the Efficacy of a Non-Surgical Treatment for Urogenital Fistula

Efriyan Imantika

^12ABCDEF*, R.M. Sonny Sasotya^1ADEF, Edwin Armawan^1ACDEF, Kevin D. Tjandraprawira^1DEF, Rodiani Rodiani^2AEF, Taufiqurrahman Rahim^2AEF

DOI: 10.12659/MSM.941641

Med Sci Monit 2023; 29:e941641

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Table 4 Gene expression of TGF-β, JAMs, and LOX in fibroblast cells treated with mucoadhesive bilayer membrane complex on the 5th and 10th days.

Gene markers	Gene expression difference		p	(95% CI)
Gene markers	Day-5th	Day-10th	p	(95% CI)
β	1.4±4.2	8.7±26.4	0.055	(−39.3–0.55)
	2.9±4.7	0.17±4.86	0.62	(1.98–7.6)
	2.97±4.7	−0.2±5.76	0.31	(−2.1–8.4)
TGF-β – tumor growth factor beta; JAMs – junctional adhesion molecules; LOX – lysil oxidase.

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Enhanced Proliferation and Adhesion Marker Gene Expression in Fibroblast Cells: Evaluating the Efficacy of a Non-Surgical Treatment for Urogenital Fistula

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