07 October 2023: Review Articles
Optimizing Delivery Strategies in Eclampsia: A Comprehensive Review on Seizure Management and Birth Methods
Marzena Laskowska 1AEF* , Anna Bednarek 2EFDOI: 10.12659/MSM.941709
Med Sci Monit 2023; 29:e941709
Background
Labor Management – Mode of Delivery
The Choice of Anesthesia
Treatment is Aimed at Stopping the Eclamptic Seizures and Preventing Their Reoccurrence and Complications
Antihypertensive Therapy and Blood Pressure Stabilization
Postpartum Care and Post-Delivery Management
Prevention
Future Directions
Conclusions
References
Table 1 The first choice of antihypertensive drugs with rapid effect by venous infusion is used for hypertensive emergencies in eclamptic women [31–34].
| Drug | Mechanism of activity | Dosage | The time when the drug starts its action | Duration of action of the drug | Side effects/contraindications |
|---|---|---|---|---|---|
| Hydralazine | 2.5–5mg | 5–20 minutes from administration [–]31 | 2–6 hours | do not use in case of tachycardia above 100 beats per minute | |
| Labetalol | Starting with a dose of 10–20 mg during the first 2 min and can be repeated with a dose of 20 mg, 40–60 mg, or 80 mg every 20–30 min, or up to a maximum dose of 300mg/day or continuous intravenous injection, in the starting dose of 1–2 mg/min, and subsequent dose of 5–10 mg/h, up to a dose of 300 mg/day [–]31 | After 5 minutes peak activity is reached in 10–20 minutes after its administration [–]31 | 6 hours | may occur bradycardia in a mother and fetus [–]31 | |
| mg – milligram; mg/h – milligram per hour; BP – blood pressure; min – minute; h – hour; HR – heart rate. | |||||