07 October 2023 : Review article
Optimizing Delivery Strategies in Eclampsia: A Comprehensive Review on Seizure Management and Birth Methods
Marzena Laskowska 1AEF*, Anna Bednarek 2EFDOI: 10.12659/MSM.941709
Med Sci Monit 2023; 29:e941709
Table 1 The first choice of antihypertensive drugs with rapid effect by venous infusion is used for hypertensive emergencies in eclamptic women [31–34].
Drug | Mechanism of activity | Dosage | The time when the drug starts its action | Duration of action of the drug | Side effects/contraindications |
---|---|---|---|---|---|
Hydralazine | 2.5–5mg | 5–20 minutes from administration [–]31 | 2–6 hours | do not use in case of tachycardia above 100 beats per minute | |
Labetalol | Starting with a dose of 10–20 mg during the first 2 min and can be repeated with a dose of 20 mg, 40–60 mg, or 80 mg every 20–30 min, or up to a maximum dose of 300mg/day or continuous intravenous injection, in the starting dose of 1–2 mg/min, and subsequent dose of 5–10 mg/h, up to a dose of 300 mg/day [–]31 | After 5 minutes peak activity is reached in 10–20 minutes after its administration [–]31 | 6 hours | may occur bradycardia in a mother and fetus [–]31 | |
mg – milligram; mg/h – milligram per hour; BP – blood pressure; min – minute; h – hour; HR – heart rate. |