20 September 2023: Clinical Research
Early Echocardiography and ECG Changes Following Radiotherapy in Patients with Stage II–III HER2-Positive Breast Cancer Treated with Anthracycline-Based Chemotherapy with or without Trastuzumab-Based Therapy
Radu Valeriu Toma 12ABCG , Zgura Anca 1E , Oana Gabriela Trifănescu 12A , Laurenţia Nicoleta Galeş 12D* , Antonia Ruxandra Folea 2CDEF , Loredana Stanca 3B , Liviu Bîlteanu 234ABCDEF* , Rodica M. Anghel 1ADOI: 10.12659/MSM.941754
Med Sci Monit 2023; 29:e941754
Supplementary Table 14 The period (in days) from the start of therapy (CHT – chemotherapy, RT – radiotherapy, TT – targeted therapy) to the time of recording the worsening or the emergence of the diastolic dysfunction through delayed relaxation (DDDR), murmurs and valvular heart disease (MVHD), cardiomyopathies and left ventricular conditions (CLVC), great vessels diseases (GVD) and pericardial disease (PD).
| DDDR | MVHD | |||||||
|---|---|---|---|---|---|---|---|---|
| CHT | TT | RT | CHT | TT | RT | |||
| Mean | 330.2 | 339.0 | 299.5 | 288.2 | 334.9 | 270.0 | ||
| SE Mean | 67.8 | 71.1 | 108.9 | 58.8 | 68.5 | 91.8 | ||
| Median | 221 | 260 | 252 | 241 | 293 | 164 | ||
| SD | 279.6 | 256.4 | 266.7 | 242.4 | 227.1 | 243.0 | ||
| Variance | 78201.7 | 65726.2 | 71144.3 | 58746.2 | 51562.3 | 59043.7 | ||
| Range | 796 | 725 | 650 | 808 | 649 | 651 | ||
| Minimum | 61 | 42 | 13 | 2 | 11 | 12 | ||
| Maximum | 857 | 767 | 663 | 810 | 660 | 663 | ||
| Percentiles | 25 | 105.0 | 123.0 | 43.0 | 97.5 | 137.0 | 142.0 | |
| 33 | 135.6 | 137.0 | 97.3 | 122.4 | 138.9 | 155.4 | ||
| 50 | 221.0 | 260.0 | 252.0 | 241.0 | 293.0 | 164.0 | ||
| 67 | 434.3 | 447.2 | 484.6 | 377.5 | 533.1 | 319.5 | ||
| 75 | 520.5 | 621.5 | 588.8 | 404.5 | 583.0 | 564.0 | ||
| Mean | 352.2 | 213.3 | 162.8 | 292.0 | 352.5 | 29 | 131 | |
| SE Mean | 47.3 | 49.9 | 54.3 | 138.8 | 259.5 | |||
| Median | 403 | 163.5 | 154 | 183 | 352.5 | 29 | 131 | |
| SD | 142.0 | 141.1 | 108.7 | 277.6 | 367.0 | |||
| Variance | 20159.4 | 19908.5 | 11810.3 | 77048.0 | 134680.5 | |||
| Range | 394 | 360 | 205 | 606 | 519 | |||
| Minimum | 130 | 42 | 69 | 98 | 93 | |||
| Maximum | 524 | 402 | 274 | 704 | 612 | |||
| Percentiles | 25 | 214.0 | 105.0 | 69.3 | 119.0 | 93.0 | ||
| 33 | 241.3 | 105.0 | 69.7 | 152.6 | 93.0 | |||
| 50 | 403.0 | 163.5 | 154.0 | 183.0 | 352.5 | |||
| 67 | 460.4 | 342.3 | 250.6 | 366.0 | . | |||
| 75 | 481.5 | 373.3 | 265.0 | 574.0 | . | |||