Early Echocardiography and ECG Changes Following Radiotherapy in Patients with Stage II-III HER2-Positive Breast Cancer Treated with Anthracycline-Based Chemotherapy with or without Trastuzumab-Based Therapy

Radu Valeriu Toma; Zgura Anca; Oana Gabriela Trifănescu; Laurenția Nicoleta Galeș; Antonia Ruxandra Folea; Loredana Stanca; Liviu Bîlteanu; Rodica M. Anghel

doi:10.12659/MSM.941754

20 September 2023 : Clinical Research

Early Echocardiography and ECG Changes Following Radiotherapy in Patients with Stage II-III HER2-Positive Breast Cancer Treated with Anthracycline-Based Chemotherapy with or without Trastuzumab-Based Therapy

Radu Valeriu Toma^{^A Study design/planning

^B Data collection/entry

^C Data analysis/statistics

^G Funds collection

" data-author="4365589">12ABCG}, Zgura Anca^1E, Oana Gabriela Trifănescu^{^A Study design/planning

" data-author="4365591">12A}, Laurenția Nicoleta Galeș^{^D Data interpretation

^*Corresponding author: [email protected]
^*Corresponding author: [email protected]
" data-author="4365592">12D*}, Antonia Ruxandra Folea^{^C Data analysis/statistics

^D Data interpretation

^E Preparation of manuscript

^F Literature analysis/search

" data-author="4365593">2CDEF}, Loredana Stanca^3B, Liviu Bîlteanu^{³Department of Preclinical Science, Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine, Bucharest, Romania
⁴Laboratory of Molecular Nanotechnologies, National Institute for Research and Development in Microtechnologies, Voluntary, Romania

^A Study design/planning

^B Data collection/entry

^C Data analysis/statistics

^D Data interpretation

^E Preparation of manuscript

^F Literature analysis/search

" data-author="4365595">234ABCDEF}, Rodica M. Anghel^1A

DOI: 10.12659/MSM.941754

Med Sci Monit 2023; 29:e941754

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Table 2 Clinical-demographic characteristics, types of comorbidities, and their coexistence in the patients included in the study.

Variable	Age (yrs)	Weight (kg)	Body mass index (kg/m2)	Body surface area (m2)
Mean	55.25	71.55	27.78	1.78
Range	48.00	82.00	30.83	1.00
Minimum	30.00	43.00	16.80	1.37
Maximum	78.00	125.00	47.63	2.37
Variable	Value		N	%
Menopause	No		18	28.6
Menopause	Yes		45	71.4
BMI Groups	Underweight (<18.5)		1	1.5
	Normal (18.5–24.9)		20	29.9
	Overweight (25.0–29.9)		25	37.3
	Obese ≥30		21	31.3
	Unknown		1
Cardiovascular (CV) diseases or diabetes mellitus/metabolic syndrome (DM/MS)	No		27	42.2
	Yes		37	57.8
CV diseases	No		25	41.0
CV diseases	Yes		36	59.0
Extended CV diseases	No		17	47.2
Extended CV diseases	Yes		19	52.8
DM/MS	No		47	78.3
DM/MS	Yes		13	21.7
CV disease and DM/MS coexistence	No		25	67.6
CV disease and DM/MS coexistence	Yes		12	32.4
Presence of inflammatory diseases	No		53	82.8
Presence of inflammatory diseases	Yes		11	17.2
Presence of several inflammatory conditions	≤1		9	81.8
Presence of several inflammatory conditions	>1		2	18.2
Chronic infections	No		56	91.8
Chronic infections	Yes		5	8.2
Thyroid disease	No		53	86.9
Thyroid disease	Yes		8	13.1

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Early Echocardiography and ECG Changes Following Radiotherapy in Patients with Stage II-III HER2-Positive Breast Cancer Treated with Anthracycline-Based Chemotherapy with or without Trastuzumab-Based Therapy

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