Early Echocardiography and ECG Changes Following Radiotherapy in Patients with Stage II-III HER2-Positive Breast Cancer Treated with Anthracycline-Based Chemotherapy with or without Trastuzumab-Based Therapy

Radu Valeriu Toma; Zgura Anca; Oana Gabriela Trifănescu; Laurenția Nicoleta Galeș; Antonia Ruxandra Folea; Loredana Stanca; Liviu Bîlteanu; Rodica M. Anghel

doi:10.12659/MSM.941754

20 September 2023 : Clinical Research

Early Echocardiography and ECG Changes Following Radiotherapy in Patients with Stage II-III HER2-Positive Breast Cancer Treated with Anthracycline-Based Chemotherapy with or without Trastuzumab-Based Therapy

Radu Valeriu Toma^{^A Study design/planning

^B Data collection/entry

^C Data analysis/statistics

^G Funds collection

" data-author="4365589">12ABCG}, Zgura Anca^1E, Oana Gabriela Trifănescu^{^A Study design/planning

" data-author="4365591">12A}, Laurenția Nicoleta Galeș^{^D Data interpretation

^*Corresponding author: [email protected]
^*Corresponding author: [email protected]
" data-author="4365592">12D*}, Antonia Ruxandra Folea^{^C Data analysis/statistics

^D Data interpretation

^E Preparation of manuscript

^F Literature analysis/search

" data-author="4365593">2CDEF}, Loredana Stanca^3B, Liviu Bîlteanu^{³Department of Preclinical Science, Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine, Bucharest, Romania
⁴Laboratory of Molecular Nanotechnologies, National Institute for Research and Development in Microtechnologies, Voluntary, Romania

^A Study design/planning

^B Data collection/entry

^C Data analysis/statistics

^D Data interpretation

^E Preparation of manuscript

^F Literature analysis/search

" data-author="4365595">234ABCDEF}, Rodica M. Anghel^1A

DOI: 10.12659/MSM.941754

Med Sci Monit 2023; 29:e941754

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Table 5 Association of the presence of changes in electrocardiographic findings with clinical factors during monitoring.

Variable	OR	95% CI	p-value	RR	95% CI

Height ≥1.64 m	7.50	(1.50, 37.394)	0.014	1.76	(1.50, 2.06)
New T-wave modification	5.20	(3.04, 210.93)	0.003	11.43	(1.66, 78.88)

[Pre-existing] modifications of T-wave in posterior leads	5.56	(1.08, 83.07)	0.043	4.60	(0.72, 29.22)

Thyroid disease	13.33	(2.16, 81.94)	0.005	6.28	(3.84, 10.29)
Age ≥58 yrs	9.45	(1.07, 83.06)	0.043	7.24	(2.99, 17.50)
Presence of chronic infections, inflammatory or thyroid-related diseases	8.20	(1.54, 43.47)	0.013	5.00	(2.98, 8.37)

New ST junction (J) or ST segment depression	6.00	(2.49, 86.03)	0.003	3.32	(0.99, 11.1)
New T-wave modification	5.19	(2.98, 57.00)	0.001	2.03	(1.24, 3.33)

New ST junction (J) or ST segment depression	6.00	(5.01, 280.90)	<0.001	2.55	(1.04, 6.26)
New T-wave modification	5.19	(1.60, 132.38)	0.017	1.39	(1.04, 1.86)

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Early Echocardiography and ECG Changes Following Radiotherapy in Patients with Stage II-III HER2-Positive Breast Cancer Treated with Anthracycline-Based Chemotherapy with or without Trastuzumab-Based Therapy

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