20 September 2023: Clinical Research
Early Echocardiography and ECG Changes Following Radiotherapy in Patients with Stage II–III HER2-Positive Breast Cancer Treated with Anthracycline-Based Chemotherapy with or without Trastuzumab-Based Therapy
Radu Valeriu Toma 12ABCG , Zgura Anca 1E , Oana Gabriela Trifănescu 12A , Laurenţia Nicoleta Galeş 12D* , Antonia Ruxandra Folea 2CDEF , Loredana Stanca 3B , Liviu Bîlteanu 234ABCDEF* , Rodica M. Anghel 1ADOI: 10.12659/MSM.941754
Med Sci Monit 2023; 29:e941754
Supplementary Table 3 List of binary ordinal variables used in this study that were defined by grouping the values of multinomial variables.
| BMI Standard Categories Grouping Model 1 | 1=Underweight and Normal range 25 |
| BMI Standard Categories Grouping Model 2 | 1=Underweight, normal range and overweight 30 |
| Positive Receptor Grouping Model 1 | 1=one positive receptor2=at least two positive receptors |
| Positive Receptor Grouping Model 2 | 1=at most two positive receptor2=three positive receptors |
| Positive Receptor Grouping Model 3 | 1=HER Positive and ER Positive2=Otherwise |
| Positive Receptor Grouping Model 4 | 1=HER Positive and PR Positive2=Otherwise |
| Positive Receptor Grouping Model 5 | 1=ER Positive and PR Positive2=Otherwise |
| Preoperative AJCC Staging Grouping Model 1 | 1=Stage 0 or Stages IA, IB2=Stages IIA, IIB, IIIA, IIIB, IIIC or IV |
| Preoperative AJCC Staging Grouping Model 2 | 1=Stage 0 or Stages IA, IB, IIA or IIB2=Stages IIIA, IIIB, IIIC or IV |
| Preoperative T Staging Grouping Model 1 | 1=T12=T2, T3 or T4 |
| Preoperative T Staging Grouping Model 2 | 1=T1 or T22=T3 or T4 |
| Preoperative T Staging Grouping Model 3 | 1=T1, T2 or T32=T4 |
| Preoperative N Staging Grouping Model 1 | 1=N0 or Nx2=N1, N2 or N3 |
| Preoperative N Staging Grouping Model 2 | 1=N0, Nx or N12=N2 or N3 |
| Cycles Number Grouping Model 1 | 1=nb. of cycles |
| Cycles Number Grouping Model 2 | 1=nb. of cycles 3 |
| Postoperative AJCC Staging Grouping Model 1 | 0=Stage 01=Any other stage |
| Postoperative AJCC Staging Grouping Model 2 | 1=Stage 0 or Stages IA, IB2=Stages IIA, IIB, IIIA, IIIB, IIIC or IV |
| Postoperative AJCC Staging Grouping Model 3 | 1=Stage 0 or Stages IA, IB, IIA or IIB2=Stages IIIA, IIIB, IIIC or IV |
| Postoperative T-staging Grouping Model 1 | 1=T0 or Tx2=T1, T2, T3 or T4 |
| Postoperative T-staging Grouping Model 2 | 1=T0, Tx or T12=T2, T3 or T4 |
| Postoperative T-staging Grouping Model 3 | 1=T0, Tx, T1 or T22=T3 or T4 |
| Postoperative T-staging Grouping Model 4 | 1=less than T4 (T0, Tx, T1, T2 or T3) 2=T4 |
| Postoperative N-staging Groups Model 1 | 1=N0 or Nx2=N1, N2 or N3 |
| Postoperative N-staging Groups Model 2 | 1=N0, Nx or N12=N2 or N3 |
| RT techniques Groups Model 1 | 1=2D2=3D or VMAT |
| RT techniques Groups Model 2 | 1=3D2=VMAT |