Early Echocardiography and ECG Changes Following Radiotherapy in Patients with Stage II-III HER2-Positive Breast Cancer Treated with Anthracycline-Based Chemotherapy with or without Trastuzumab-Based Therapy

Radu Valeriu Toma; Zgura Anca; Oana Gabriela Trifănescu; Laurenția Nicoleta Galeș; Antonia Ruxandra Folea; Loredana Stanca; Liviu Bîlteanu; Rodica M. Anghel

doi:10.12659/MSM.941754

20 September 2023 : Clinical Research

Early Echocardiography and ECG Changes Following Radiotherapy in Patients with Stage II-III HER2-Positive Breast Cancer Treated with Anthracycline-Based Chemotherapy with or without Trastuzumab-Based Therapy

Radu Valeriu Toma^{^A Study design/planning

^B Data collection/entry

^C Data analysis/statistics

^G Funds collection

" data-author="4365589">12ABCG}, Zgura Anca^1E, Oana Gabriela Trifănescu^{^A Study design/planning

" data-author="4365591">12A}, Laurenția Nicoleta Galeș^{^D Data interpretation

^*Corresponding author: [email protected]
^*Corresponding author: [email protected]
" data-author="4365592">12D*}, Antonia Ruxandra Folea^{^C Data analysis/statistics

^D Data interpretation

^E Preparation of manuscript

^F Literature analysis/search

" data-author="4365593">2CDEF}, Loredana Stanca^3B, Liviu Bîlteanu^{³Department of Preclinical Science, Faculty of Veterinary Medicine, University of Agronomic Sciences and Veterinary Medicine, Bucharest, Romania
⁴Laboratory of Molecular Nanotechnologies, National Institute for Research and Development in Microtechnologies, Voluntary, Romania

^A Study design/planning

^B Data collection/entry

^C Data analysis/statistics

^D Data interpretation

^E Preparation of manuscript

^F Literature analysis/search

" data-author="4365595">234ABCDEF}, Rodica M. Anghel^1A

DOI: 10.12659/MSM.941754

Med Sci Monit 2023; 29:e941754

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Supplementary Table 4 Tumor pre- and post-treatment staging and histology.

Characteristic	Value		N				%
Tumor localization	Left		48				70.6
Tumor localization	Right		20				29.4



Tumor (T)	T0 or Tx		0		0.0		9		15.3
	T1		6		9.1		23		39.0
	T2		37		56.1		21		35.6
	T3		11		16.7		3		5.1
	T4		12		18.2		3		5.1
	Missing		2				9
Nodal status (N)	N0 or Nx		19		28.8		29		49.2
	N1		35		53.0		19		32.2
	N2		10		15.2		8		13.6
	N3		2		3.0		3		5.1
	Missing		2				0



	0	2	0	1	0	0	0	0	3	4.9
	1	0	0	1	0	0	0	0	2	3.3
	1	3	0	2	1	1	1	0	9	14.8
	1	2	0	7	4	3	0	3	0	32.8
	1	6	0	4	2	1	0	0	14	23.0
	2	1	1	3	1	2	2	1	13	21.3
	6	14	1	18	8	7	3	4	61^*
	9.8	23.0	1.6	29.5	13.1	11.5	4.9	6.6	61^*
^* Only the patients for whom we had pre-therapeutic and post-therapeutic staging data were included in this table.

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Early Echocardiography and ECG Changes Following Radiotherapy in Patients with Stage II-III HER2-Positive Breast Cancer Treated with Anthracycline-Based Chemotherapy with or without Trastuzumab-Based Therapy

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