30 October 2023: Clinical Research
Serum Inflammatory Cytokine Levels in Herpes Zoster Patients and Their Association with Postherpetic Neuralgia: A Prospective Study
Jing Gu ABEF* , Yanrong Yuan BD* , Jun Wang CF , Huili Liu BD , Zuyong Zhang G* , Yongxing Yan CD*DOI: 10.12659/MSM.941878
Med Sci Monit 2023; 29:e941878
Table 2 Comparison of serum inflammatory cytokines levels in HZ patients in different pain groups.
| Without pain group (n= 9) | Mild pain group (n=86) | Moderate pain group (n=50) | Severe pain group (n=24) | F | P | |
|---|---|---|---|---|---|---|
| Age(x±s)(years) | 53.3±19.5 | 65.0±12.8* | 65.2±13.2* | 76.1±10.2** | 7.909 | 0.0000 |
| Gender | ||||||
| Male (cases, %) | 5 (55.6) | 34 (39.5) | 29 (58.0) | 11 (45.8) | 4.629 | 0.2010 |
| Female (cases, %) | 4 (44.4) | 52 (60.5) | 21 (42.0) | 13 (54.2) | ||
| Herpes site (number of cases, %) | ||||||
| Head and face | 4 (44.4) | 29 (33.7) | 21 (42.0) | 10 (41.7) | 2.514 | 0.4728 |
| Neck | 1 (11.1) | 11 (12.8) | 2 (4.0) | 2 (8.3) | 2.370 | 0.4991 |
| Chest and Back | 2 (22.2) | 25 (29.1) | 13 (26.0) | 7 (29.2) | 0.078 | 0.9943 |
| Waist | 2 (22.2) | 18 (20.9) | 9 (18.0) | 4 (16.7) | 0.257 | 0.9700 |
| Limbs | 0 (0) | 13 (15.1) | 5 (10.0) | 3 (12.5) | 1.659 | 0.6462 |
| VAS score | 0 | 2.12±0.8 | 4.72±0.8 | 7.7±0.9 | 397.5 | 0.0000 |
| TNF-α (pg/ml) | 8.8±3.7 | 7.9±3.0 | 6.7±2.3* | 6.3±1.9* | 4.14 | 0.0073 |
| IL-1β (pg/ml) | 3.4±3.6 | 4.1±2.8 | 4.9±2.8 | 4.6±2.3 | 1.354 | 0.2587 |
| IL-2R (u/ml) | 421.2±261.2 | 418.6±187.4 | 496.8±212.2 | 499.0±327.8 | 1.723 | 0.1642 |
| IL-6 (pg/ml) | 2.0 (1.2–3.2) | 2.9 (2.0–5.4) | 2.7 (2.0–5.0) | 4.1 (2.1–8.4) | 2.539 | 0.0384 |
| IL-8 (pg/ml) | 10.2 (6.0–27.4) | 12.5 (7.8–18.0) | 11.9 (6.9–18.0) | 15.7 (8.2–38.2) | 2.577 | 0.0356 |
| IL-10 (pg/ml) | 3.0±1.3 | 3.8±1.5 | 5.4±2.5** | 8.6±6.5** | 17.80 | 0.0000 |
| Compared with without pain group, * | ||||||