17 November 2023 : Clinical Research
Hypothalamic Injury and Clinical Outcomes in Patients with Post-Traumatic Hyponatremia: A Diffusion Tensor Imaging Case-Control Study
Sung Ho Jang1ABCDEF, Min Soo Kang1ABCDEF*, Kyu Hyang Cho2ADE, Jung Hwan Park1EFDOI: 10.12659/MSM.942397
Med Sci Monit 2023; 29:e942397
Table 1 Comparisons of demographic data, clinical factors, level of consciousness assessments, and clinical outcomes between the 2 patient groups.
| Variables | Group A | Group B | p-value |
|---|---|---|---|
| Patients, n | 18 | 18 | |
| Age, years | 57.4±16.5 | 47.6±17.9 | 0.096 |
| Sex, (Male/Female) | 16/2 | 14/4 | 0.371 |
| Previous medical history, n (%) | |||
| Hypertension | 6 (33.3%) | 5 (27.8%) | 0.717 |
| Diabetes mellitus | 3 (16.7%) | 2 (11.1%) | 0.630 |
| Dyslipidemia | 3 (16.7%) | 1 (5.6%) | 0.289 |
| Heart disease | 2 (11.1%) | 2 (11.1%) | 1.000 |
| Chronic kidney disease | 3 (16.7%) | 0 (0.0%) | 0.070 |
| Presence of traumatic intracranial hemorrhage, n (%) | 16 (88.9%) | 16 (88.9%) | 1.000 |
| Presence of diffuse axonal injury, n (%) | 17 (94.4%) | 18 (100.0%) | 0.735 |
| Use of mannitol injections, n (%) | 10 (55.6%) | 11 (61.1%) | 0.735 |
| Use of diuretics, n (%) | 4 (22.2%) | 1 (5.6%) | 0.148 |
| Use of anti-depressants, n (%) | 17 (94.4%) | 17 (94.4%) | 1.000 |
| Brain surgery history after TBI, n (%) | 11 (61.1%) | 7 (38.9%) | 0.182 |
| GCS score at admission | 5.78±2.84 | 5.83±2.79 | 0.617 |
| CRS-R score at admission | 4.72±4.92 | 4.44±3.78 | 0.886 |
| Clinical outcome | |||
| Length of hospital stay, days | 107.06±26.98 | 82.56±37.12 | 0.030* |
| CRS-R score at discharge | 15.72±5.93 | 20.5±4.09 | 0.010* |
| Change in the CRS-R score | 11±5.11 | 16.06±4.56 | 0.004* |
| Values are presented as the mean±standard deviation. TBI – traumatic brain injury; GCS – Glasgow Coma Scale; CRS-R – Coma Recovery Scale-Revised. * Significantly different between the 2 groups, at | |||