Hypothalamic Injury and Clinical Outcomes in Patients with Post-Traumatic Hyponatremia: A Diffusion Tensor Imaging Case-Control Study

Sung Ho Jang; Min Soo Kang; Kyu Hyang Cho; Jung Hwan Park

doi:10.12659/MSM.942397

17 November 2023 : Clinical Research

Hypothalamic Injury and Clinical Outcomes in Patients with Post-Traumatic Hyponatremia: A Diffusion Tensor Imaging Case-Control Study

Sung Ho Jang^1ABCDEF, Min Soo Kang^1ABCDEF*, Kyu Hyang Cho^2ADE, Jung Hwan Park^1EF

DOI: 10.12659/MSM.942397

Med Sci Monit 2023; 29:e942397

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Table 3 Correlations between the severity of hyponatremia, diffusion tensor imaging parameters of the hypothalamus, and the coma recovery scale-revised scores at admission, discharge, and the changes from admission to discharge.

		Severity of hyponatremia	DTI parameters
		Severity of hyponatremia	FA	ADC
Severity of hyponatremia	r	N/A	−0.258	0.475**
Severity of hyponatremia	-value	N/A	0.128	0.003*
CRS-R score at admission	r	−0.012	0.154	−0.079
CRS-R score at admission	-value	0.947	0.371	0.645
CRS-R score at discharge	r	−0.382**	0.004	−0.340**
CRS-R score at discharge	-value	0.022*	0.980	0.042*
Change in CRS-R score	r	−0.467**	0.140	−0.220
Change in CRS-R score	-value	0.004*	0.414	0.197
The correlation coefficient (value) represents the positive or negative strength of the relationship (0.1–0.29, weak; 0.3–0.49, moderate; ≤0.5, strong*). N/A – not applicable; CRS-R – Coma Recovery Scale-Revised; DTI – diffusion tensor imaging; FA – fractional anisotropy; ADC – apparent diffusion coefficient. ^ Statistically significant, at

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Hypothalamic Injury and Clinical Outcomes in Patients with Post-Traumatic Hyponatremia: A Diffusion Tensor Imaging Case-Control Study

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