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21 May 2024: Clinical Research

Protective Role of TRPC3 Gene Polymorphism (rs10518289) in Obstructive Sleep Apnea Hypopnea Syndrome Among Hypertensive Patients

Yu Li 1CDE* , Reyihanguli Shataer 2BC* , Yulan Chen 3ABCFG* , Xiaoli Zhu 4B , Xiaojing Sun 5AB

DOI: 10.12659/MSM.942667

Med Sci Monit 2024; 30:e942667

Table 4 Comparison of the frequency distribution of TRPC3 genotypes in the EH group and EH+OSAHS group.

TRPC3 geneTypeGenotypeEH group (n=74) n (%)]EH+OSHAS group (n=299) [n (%)]χ2 valueP value
Rs953691GenotypeGG23 (31.1)99 (33.1)0.3050.85948
GT32 (43.2)132 (44.1)
TT19 (25.7)68 (22.7)
AlleleG55 (51.9)231 (53.6)0.1000.752
T51 (48.1)200 (46.4)
Dominant modelGG23 (31.1)99 (33.1)0.1110.739
TT+GT51 (68.9)200 (66.9)
Recessive modelTT19 (25.7)68 (22.7)0.2850.593
GG+GT55 (74.3)231 (77.3)
Additive modelCT32 (43.2)132 (44.1)0.0200.888
CC+TT42 (56.8)167 (55.9)
Rs10518289GenotypeCC23 (31.1)48 (16.1)9.8030.007
CG32 (43.2)136 (45.5)
GG19 (25.7)115 (38.5)
AlleleC55 (51.9)184 (42.3)3.1770.075
G51 (48.1)251 (57.7)
Dominant modelCC23 (31.1)48 (16.1)8.6920.003
GG+CG51 (68.9)251 (83.9)
Recessive modelGG19 (25.7)115 (38.5)4.2130.040
CC+CG55 (74.3)184 (61.5)
Additive modelCG32 (43,2)136 (45.5)0.1200.729
CC+GG42 (56.8)163 (54.5)
Rs2292232GenotypeGG25 (33.8)97 (32.4)0.2700.874
GT31 (41.9)135 (45.2)
TT18 (24.3)67 (22.4)
AlleleG56 (53.3)232 (53.5)0.0010.982
T49 (46.7)202 (46.5)
Dominant modelGG25 (33.8)97 (32.4)0.0490.826
TT+GT49 (66.2)202 (67.6)
Recessive modelTT18 (24.3)67 (41.9)5.1560.023
GG+GT56 (75.7)232 (58.1)
Additive modelGT31 (41.9)135 (45.2)0.2550.614
GG+TT43 (58.1)164 (54.8)
Rs4995894GenotypeGG55 (74.3)220 (73.6)0.0200.990
GC17 (23.0)71 (23.7)
CC2 (2.7)8 (2.7)
AlleleG72 (79.1)291 (78.6)0.0100.921
C19 (20.9)79 (21.4)
Dominant modelGG55 (74.3)220 (73.6)0.0170.896
CC+CG19 (25.7)79 (26.4)
Recessive modelCC2 (2.7)8 (2.7)0.0000.990
GG +CG72 (97.3)291 (97.3)
Additive modelCG17 (23)71 (23.7)0.0200.889
CC+GG57 (77)228 (76.3)
Rs951974GenotypeGG19 (25.7)68 (22.7)0.4410.840
GT31 (41.9)137 (45.8)
TT24 (32.4)94 (31.4)
AlleleG50 (47.6)205 (47.0)0.0120.912
T55 (52.4)231 (53)
Dominant modelGG19 (25.7)68 (22.7)0.2850.593
GT +TT55 (74.3)231 (77.3)
Recessive modelTT24 (32.4)94 (31.4)0.0270.869
GG+GT50 (67.6)205 (68.6)
Additive modelGT31 (41.9)137 (45.8)0.3700.543
TT+ GG43 (58.1)162 (54.2)
Rs4292355GenotypeCC50 (67.6)205 (68.6)2.8690.732
CT24 (32.4)84 (28.1)
TT0 (0)10 (3.3)
AlleleC74 (75.5)289 (96.7)42.1430.000
T24 (24.5)10 (3.3)
Dominant modelCC50 (67.6)205 (68.6)0.0270.869
CT+TT24 (32.4)94 (31.4)
Recessive modelTT0 (0)10 (3.3)2.5430.111
CT+CC74 (100)289 (96.7)
Additive modelCT24 (32.4)84 (28.1)0.5430.461
CC+TT50 (67.6)215 (71.9)

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750