21 May 2024 : Clinical Research
Protective Role of TRPC3 Gene Polymorphism (rs10518289) in Obstructive Sleep Apnea Hypopnea Syndrome Among Hypertensive Patients
Yu Li1CDE, Reyihanguli Shataer2BC, Yulan Chen3ABCFG*, Xiaoli Zhu4B, Xiaojing Sun5ABDOI: 10.12659/MSM.942667
Med Sci Monit 2024; 30:e942667
Table 4 Comparison of the frequency distribution of TRPC3 genotypes in the EH group and EH+OSAHS group.
| TRPC3 gene | Type | Genotype | EH group (n=74) n (%)] | EH+OSHAS group (n=299) [n (%)] | χ2 value | P value |
|---|---|---|---|---|---|---|
| Rs953691 | Genotype | GG | 23 (31.1) | 99 (33.1) | 0.305 | 0.85948 |
| GT | 32 (43.2) | 132 (44.1) | ||||
| TT | 19 (25.7) | 68 (22.7) | ||||
| Allele | G | 55 (51.9) | 231 (53.6) | 0.100 | 0.752 | |
| T | 51 (48.1) | 200 (46.4) | ||||
| Dominant model | GG | 23 (31.1) | 99 (33.1) | 0.111 | 0.739 | |
| TT+GT | 51 (68.9) | 200 (66.9) | ||||
| Recessive model | TT | 19 (25.7) | 68 (22.7) | 0.285 | 0.593 | |
| GG+GT | 55 (74.3) | 231 (77.3) | ||||
| Additive model | CT | 32 (43.2) | 132 (44.1) | 0.020 | 0.888 | |
| CC+TT | 42 (56.8) | 167 (55.9) | ||||
| Rs10518289 | Genotype | CC | 23 (31.1) | 48 (16.1) | 9.803 | 0.007 |
| CG | 32 (43.2) | 136 (45.5) | ||||
| GG | 19 (25.7) | 115 (38.5) | ||||
| Allele | C | 55 (51.9) | 184 (42.3) | 3.177 | 0.075 | |
| G | 51 (48.1) | 251 (57.7) | ||||
| Dominant model | CC | 23 (31.1) | 48 (16.1) | 8.692 | 0.003 | |
| GG+CG | 51 (68.9) | 251 (83.9) | ||||
| Recessive model | GG | 19 (25.7) | 115 (38.5) | 4.213 | 0.040 | |
| CC+CG | 55 (74.3) | 184 (61.5) | ||||
| Additive model | CG | 32 (43,2) | 136 (45.5) | 0.120 | 0.729 | |
| CC+GG | 42 (56.8) | 163 (54.5) | ||||
| Rs2292232 | Genotype | GG | 25 (33.8) | 97 (32.4) | 0.270 | 0.874 |
| GT | 31 (41.9) | 135 (45.2) | ||||
| TT | 18 (24.3) | 67 (22.4) | ||||
| Allele | G | 56 (53.3) | 232 (53.5) | 0.001 | 0.982 | |
| T | 49 (46.7) | 202 (46.5) | ||||
| Dominant model | GG | 25 (33.8) | 97 (32.4) | 0.049 | 0.826 | |
| TT+GT | 49 (66.2) | 202 (67.6) | ||||
| Recessive model | TT | 18 (24.3) | 67 (41.9) | 5.156 | 0.023 | |
| GG+GT | 56 (75.7) | 232 (58.1) | ||||
| Additive model | GT | 31 (41.9) | 135 (45.2) | 0.255 | 0.614 | |
| GG+TT | 43 (58.1) | 164 (54.8) | ||||
| Rs4995894 | Genotype | GG | 55 (74.3) | 220 (73.6) | 0.020 | 0.990 |
| GC | 17 (23.0) | 71 (23.7) | ||||
| CC | 2 (2.7) | 8 (2.7) | ||||
| Allele | G | 72 (79.1) | 291 (78.6) | 0.010 | 0.921 | |
| C | 19 (20.9) | 79 (21.4) | ||||
| Dominant model | GG | 55 (74.3) | 220 (73.6) | 0.017 | 0.896 | |
| CC+CG | 19 (25.7) | 79 (26.4) | ||||
| Recessive model | CC | 2 (2.7) | 8 (2.7) | 0.000 | 0.990 | |
| GG +CG | 72 (97.3) | 291 (97.3) | ||||
| Additive model | CG | 17 (23) | 71 (23.7) | 0.020 | 0.889 | |
| CC+GG | 57 (77) | 228 (76.3) | ||||
| Rs951974 | Genotype | GG | 19 (25.7) | 68 (22.7) | 0.441 | 0.840 |
| GT | 31 (41.9) | 137 (45.8) | ||||
| TT | 24 (32.4) | 94 (31.4) | ||||
| Allele | G | 50 (47.6) | 205 (47.0) | 0.012 | 0.912 | |
| T | 55 (52.4) | 231 (53) | ||||
| Dominant model | GG | 19 (25.7) | 68 (22.7) | 0.285 | 0.593 | |
| GT +TT | 55 (74.3) | 231 (77.3) | ||||
| Recessive model | TT | 24 (32.4) | 94 (31.4) | 0.027 | 0.869 | |
| GG+GT | 50 (67.6) | 205 (68.6) | ||||
| Additive model | GT | 31 (41.9) | 137 (45.8) | 0.370 | 0.543 | |
| TT+ GG | 43 (58.1) | 162 (54.2) | ||||
| Rs4292355 | Genotype | CC | 50 (67.6) | 205 (68.6) | 2.869 | 0.732 |
| CT | 24 (32.4) | 84 (28.1) | ||||
| TT | 0 (0) | 10 (3.3) | ||||
| Allele | C | 74 (75.5) | 289 (96.7) | 42.143 | 0.000 | |
| T | 24 (24.5) | 10 (3.3) | ||||
| Dominant model | CC | 50 (67.6) | 205 (68.6) | 0.027 | 0.869 | |
| CT+TT | 24 (32.4) | 94 (31.4) | ||||
| Recessive model | TT | 0 (0) | 10 (3.3) | 2.543 | 0.111 | |
| CT+CC | 74 (100) | 289 (96.7) | ||||
| Additive model | CT | 24 (32.4) | 84 (28.1) | 0.543 | 0.461 | |
| CC+TT | 50 (67.6) | 215 (71.9) |