Protective Role of TRPC3 Gene Polymorphism (rs10518289) in Obstructive Sleep Apnea Hypopnea Syndrome Among Hypertensive Patients

21 May 2024 : Clinical Research

Yu Li^1CDE, Reyihanguli Shataer^2BC, Yulan Chen^3ABCFG*, Xiaoli Zhu^4B, Xiaojing Sun^5AB

DOI: 10.12659/MSM.942667

Med Sci Monit 2024; 30:e942667

Introduction Material and Methods Results Discussion Conclusions References

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Table 5 Logistic regression analysis of factors influencing OSAHS in patients with essential hypertension.

	B	SE	Wald χ2	P value	OR value	95% CI
Rs10518289 dominant model (CC vs CG+GG)	−0.774	0.348	4.961	0.026	0.461	0.233~0.911
Genger	−0.074	0.486	2.315	0.128	0.477	0.184~1.238
Smoking history	0.187	0.378	0.244	0.621	1.205	0.575~2.529
Alcohol history	−0.331	0.383	0.749	0.387	1.393	0.659~2.949
Hypertension history	−0.002	0.003	0.603	0.438	0.998	0.993~1.003
Age	0.074	0.020	13.833	0.000	1.077	1.036~1.120
FPG	−0.070	0.137	0.257	0.612	0.933	0.713~1.221
BMI	0.235	0.057	16.919	0.000	1.265	1.131~1.415
TG	0.310	0.225	1.904	0.168	1.364	0.878~2.119
TC	0.030	0.561	0.003	0.958	1.030	0.343~3.092
HDL-C	0.524	0.682	0.589	0.443	1.688	0.443~6.432
LDL-C	−0.105	0.617	0.029	0.865	0.900	0.269~3.016
GHb	0.041	0.240	0.029	0.866	1.042	0.651~1.668
urea	−0.039	0.123	0.102	0.749	0.961	0.755~1.224
Creatinine	−0.014	0.011	1.500	0.221	0.986	0.965~1.008
24-h MSBP	−0.002	0.020	0.013	0.910	1.002	0.964~1.042
24-h MDBP	−0.005	0.026	0.039	0.844	0.995	0.946~1.046
EH=0, EH+OSAHS=1; genger (male=1, female=0); smoking history (yes=1, no=0); alcohol history (yes=1,no=0); Rs10518289 genotype (CC=1,CG+GG=2).

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