23 February 2024>: Clinical Research
Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion
Monika Kamianowska 1ACDE* , Agnieszka Rybi-Szumińska 2AD , Aleksandra Kamianowska 2CEF , Mateusz Maciejczyk 3C , Anna Zubrzycka 1B , Joanna Nazarko 1B , Anna Wasilewska 2ACDEDOI: 10.12659/MSM.942819
Med Sci Monit 2024; 30:e942819
Table 3 The concentrations of the assessed biomarkers and the values of the biomarker/Cr ratios.
Parameters | All neonates (N=80) | Boys (N=40) | Girls (N=40) | p |
---|---|---|---|---|
Median (Q1–Q3) | ||||
Urine creatinine (mg/dl) | 75.55 (42.64–114.28) | 72.36 (45.19–97.87) | 75.55 (40.64–135.03) | NS |
Calbindin (ng/ml) | 130.75 (29.83–359.95) | 130.75 (23.50–370.96) | 133.71 (32.48–307.07) | NS |
Calbindin/cr. (ng/mg cr.) | 197.04 (56.25–595.17) | 266.95 (38.57–658.48) | 153.24 (71.10–456.62) | NS |
KIM-1 (ng/ml) | 0.07 (0.02–0.14) | 0.05 (0.01–0.14) | 0.08 (0.02–0.13) | NS |
KIM-1/cr. (ng/mg cr.) | 0.09 (0.04–0.18) | 0.07 (0.03–0.18) | 0.12 (0.04–0.17) | NS |
MCP-1 (ng/ml) | 0.03 (0.01–0.07) | 0.03 (0.01–0.08) | 0.03 (0.01–0.06) | NS |
MCP-1/cr. (ng/mg cr.) | 0.05 (0.02–0.14) | 0.05 (0.01–0.15) | 0.04 (0.02–0.13) | NS |
B2M (ng/ml) | 54.56 (13.02–200.09) | 50.61 (12.07–200.09) | 61.91 (14.63–281.31) | NS |
B2M/cr. (ng/mg cr.) | 126.12 (19.03–342.48) | 125.33 (15.07–321.17) | 153.50 (25.35–393.60) | NS |
GST-pi (ng/ml) | 2.28 (0.63–10.42) | 0.76 (0.35–1.62) | 6.97 (2.51–16.79) | p |
GST-pi/cr. (ng/mg cr.) | 2.83 (1.01–13.12) | 1.28 (0.46–3.77) | 8.66 (2.51–27.82) | p |
Clusterin (ng/ml) | 2.03 (1.04–9.63) | 1.89 (0.93–9.63) | 2.03 (1.17–9.58) | NS |
Clusterin/cr. (ng/mg cr.) | 4.55 (1.79–12.97) | 4.46 (1.58–13.28) | 4.58 (1.91–12.80) | NS |
NS – non-significant; Q1-Q3 – interquartile range; – comparison of males and females; GST-pi – glutathione-S-transferase-pi; KIM-1 – kidney injury molecule-1; MCP-1 – monocyte chemoattractant protein-1; B2M – beta-2-microglobulin. |