23 February 2024: Clinical Research
Urinary Concentration of Renal Biomarkers in Healthy Term Neonates: Gender Differences in GST-pi Excretion
Monika Kamianowska 1ACDE* , Agnieszka Rybi-Szumińska 2AD , Aleksandra Kamianowska 2CEF , Mateusz Maciejczyk 3C , Anna Zubrzycka 1B , Joanna Nazarko 1B , Anna Wasilewska 2ACDEDOI: 10.12659/MSM.942819
Med Sci Monit 2024; 30:e942819
Table 8 Studies concerning urinary calbindin, clusterin, glutathione-S-transferase-pi (GST-pi); kidney injury molecule-1 (KIM-1); monocyte chemoattractant protein-1 (MCP-1); beta-2-microglobulin (B2M).
| Biomarker | Studies concerning biomarker’s urinary concentration |
|---|---|
| Concentration in stable preterm neonates (median (Q1–Q3): 0.52 (0.14–1.53) ng/ml []Concentration in preterm neonates (birth weight ≤1200 g and/or GA ≤31 weeks) without AKI (mean (Q1–Q3): 8.73 (6.30–15.9) ng/ml []Value of the calbindin/Cr ratio in preterm neonates (birth weight ≤1200 g and/or GA ≤31 weeks) without AKI (median (Q1–Q3): 69.7 (49.4–115) ng/mg Cr []Value of the calbindin/Cr. ratio in healthy adults (mean±SD): 2.44±0.31 ng/mg Cr []Concentration in healthy adults – 95% CI: 0.31–114.0 ng/mL []Value of the calbindin/Cr ratio in healthy adults – 95% CI: 1.6–133.3 ng/mg Cr []15 | |
| Concentration in stable preterm neonates (median (Q1–Q3): 834.40 (107.40–2511.00) ng/ml []Concentration in preterm neonates (birth weight ≤1200 g and/or GA ≤31 weeks) without AKI (mean (Q1–Q3): 245 (163–390) ng/ml []Value of the clusterin/Cr ratio in preterm neonates (birth weight ≤1200 g and/or GA ≤31 weeks) without AKI (median (Q1–Q3): 1690 (1140–3340) ng/mg Cr []Concentration in healthy adults (median [Q1–Q3]): 8.6 (3.2–16.1) ng/ml []Value of the clusterin/Cr. ratio in healthy adults (median [Q1–Q3]): 7.7 (3.9–16.3) []Concentration in healthy adults – 95% CI: 0.00–70.00 ng/mL []Value of the clusterin/Cr ratio healthy adults – 95% CI: 10–150 ng/mg Cr []15 | |
| Concentration in preterm neonates (median (Q1–Q3): 6.5 (4.1–8.1) ng/ml []Value of the GST-pi/Cr ratio in preterm neonates in the 1 week (mean±SD): 35.2±32.3 ng/mg Cr []Value of the GST-pi/Cr ratio in preterm neonates in the 4 week (mean±SD): 43.6±31.0 ng/mg Cr []Value of the GST-pi/Cr ratio in healthy adults (mean±SD): 8±6.4 ng/mg Cr []27 | |
| Concentration in stable preterm neonates (median [Q1–Q3]: 0.12 [0.08–0.17]) ng/ml []Concentration in preterm neonates (birth weight ≤1200 g and/or GA ≤31 weeks) without AKI (mean (Q1–Q3): 3.45 (1.97–6.77) ng/ml []Value of the KIM-1/Cr. ratio in preterm neonates (birth weight ≤1200 g and/or GA ≤31 weeks) without AKI (median (Q1–Q3): 27.3 (17.1–50.9) ng/mg Cr []Concentration in stable very low birth weight neonates on 1 day of life (median [Q1–Q3]): 0.42 (0.25–0.77) ng/ml []Concentration in healthy adults – 95% CI: 0.05–0.48 ng/mL []Value of the KIM-1/Cr ratio in healthy adults – 95% CI: 0.11–0.90 ng/mg Cr []Concentration in healthy term neonates (median [Q1–Q3]): 1.262 (0.634–2.522) []Value of the KIM-1/Cr ratio in healthy term neonates (median [Q1–Q3]): 2.111 (1.222–3.266) []Value of the KIM-1/Cr ratio in children (median): 0.36 ng/mg Cr []Concentration in healthy term neonates (median): 0.08 ng/ml []15 | |
| Concentration in healthy children (mean±SD): 0.07±0.02 ng/ml []Concentration in healthy children (mean±SD): 0.34±0.08 ng/ml []Concentration in healthy adults (mean±SD): 0.144±0.137 ng/ml []Concentration in healthy adults (median [Q1–Q3]): 0.19 (0.10–0.34) ng/ml []75 | |
| Concentration in preterm neonates (birth weight ≤1200 g and/or GA ≤31 weeks) without AKI (mean (Q1–Q3): 12 100 (8200–15 600) ng/ml []Value of the B2M/Cr ratio in preterm neonates (birth weight ≤1200 g and/or GA ≤31 weeks) without AKI (median (Q1–Q3): 99 300 (66 300–154 000) ng/mg Cr []Concentration in preterm neonates (median (Q1–Q3): 5500 (3600–7500) ng/ml []Concentration in healthy adults – 95% CI: 10–90 ng/mL []Value of the B2M/Cr ratio in healthy adults – 95% CI: 30–180 ng/mg Cr []26 | |
| GST-pi – glutathione-S-transferase-pi; KIM-1 – kidney injury molecule-1; MCP-1 – monocyte chemoattractant protein-1; B2M – beta-2-microglobulin; 95% CI – 95% confidence interval; Cr – creatinine; AKI – acute kidney injury; GA – gestational age; SD – standard deviation; Q1 – first quartile; Q3 – third quartile. | |