07 February 2024: Clinical Research
Predicting Severity in Hypertriglyceridemia-Induced Acute Pancreatitis: The Role of Neutrophils, Calcium, and Apolipoproteins
Ying-qiu Hu 1DE , Xia Tao 1B , Hai-bo Wu 1E , Wu-gen Li 2D , Ding-yi Chen 1F , Yuan-fei Liu 1G , Shao-yu Tao 1F , Kai-yang Wang 1A*DOI: 10.12659/MSM.942832
Med Sci Monit 2024; 30:e942832
Table 1 General clinical characteristics of MSAP/SAP and MAP groups.
| Parameter | MAP (n=71) | MSAP/SAP (n=56) | P value | Normal reference range |
|---|---|---|---|---|
| Age(y) media (P-P) | 39.59 (37.47, 41.71) | 37.25 (34.85, 39.65) | 0.146 | --- |
| Male gender(%) | 55 (77.46) | 47 (83.93) | 0.145 | --- |
| From start of pain to hospaital (h) media (P–P) | 16.00 (IQR 18.43, 29.26) | 24.00 (IQR 17.18, 42.96) | 0.544 | --- |
| Pancreatitis (%) | 38 | 33.9 | 0.633 | --- |
| Coexisting condition (%) | ||||
| Hyperlipemia | 28.2 | 17.9 | 0.174 | --- |
| Diabetes | 26.8 | 25 | 0.822 | --- |
| Hyperpiesia | 12.7 | 8.9 | 0.503 | --- |
| WBC(×10) (X±s) | 13.17±0.45 | 14.68±0.65 | 0.057 | 3.50–9.50 |
| PLT(×10) (X±s) | 244.28±8.38 | 230.41±9.50 | 0.275 | 125–350 |
| HCT(%) (X±s) | 44.16±0.51 | 46.67±0.81 | 0.006 | 40–50 |
| NEUT(%) media (P–P) | 81.4 (IQR 75.60, 86.20) | 85.40 (IQR 81.25, 90.25) | 0.000 | 40–75 |
| NEUT(×10) (X±s) | 10.70±0.45 | 12.82±0.59 | 0.055 | 2–7 |
| LYM(×10) media (P–P) | 1.64 (IQR 0.92, 2.24) | 1.03 (IQR 0.63, 1.65) | 0.016 | 20–50 |
| NLR media (P–P) | 6.93 (IQR 4.74, 11.56) | 12.09 (IQR 7.70, 11.49) | 0.001 | --- |
| TP (g/L) media (P–P) | 73.42 (IQR 67.06, 81.90) | 71.42 (IQR 62.31, 89.05) | 0.622 | 65–85 |
| ALB (g/L) media (P–P) | 41.12 (IQR 39.04, 43.76) | 40.18 (IQR 36.28, 44.06) | 0.264 | 40–55 |
| TBIL (umol/L) media (P–P) | 15.51 (IQR 12.13, 19.08) | 18.73 (IQR 12.72, 44.98) | 0.048 | 0–23 |
| DBIL (umol/L) media (P–P) | 2.16 (IQR 1.27, 3.19) | 3.46 (IQR 1.90, 6.65) | 0.001 | 0–4 |
| IBIL (umol/L) media (P–P) | 13.13 (IQR 10.63, 16.28) | 15.92 (IQR 9.87, 19.93) | 0.377 | 0–19 |
| ALT(U/L) media (P–P) | 29.30 (IQR 18.58, 45.63) | 23.85 (IQR 18.89, 37.05) | 0.118 | 7–40 |
| AST(U/L) media (P–P) | 24.25 (IQR 18.17, 33.70) | 30.28 (IQR 21.32, 44.91) | 0.033 | 13–35 |
| ALP(U/L) media (P–P) | 78.02 (IQR 66.81, 108.62) | 77.63 (IQR 60.55, 97.29) | 0.129 | 50–150 |
| UREA (umol/L) media (P–P) | 4.63 (IQR 3.84, 5.56) | 4.77 (IQR 3.76, 6.82) | 0.356 | 2.6–7.5 |
| Cre (umol/L) media (P–P) | 52.20 (IQR 37.33, 65.71) | 58.51 (IQR 44.38, 77.63) | 0.039 | 41–73 |
| Na (mmol/L) media (P–P) | 132.60 (IQR 128.71, 135.43) | 129.60 (IQR 125.08, 133.23) | 0.008 | 135–147 |
| Ca (mmol/L) media (P–P) | 2.38 (IQR 2.29, 2.47) | 2.15 (IQR 1.86, 2.40) | 0.000 | 2.11–2.52 |
| TC (mmol/L)media (P–P) | 10.84 (IQR 8.75, 14.51) | 12.67 (IQR 9.80, 16.80) | 0.175 | |
| TG (mmol/L)media (P–P) | 22.68 (IQR 17.66, 33.54) | 22.99 (IQR 16.84, 33.65) | 0.944 | |
| HDL (mmol/L) media (P–P) | 0.87 (IQR 0.56, 1.20) | 0.87 (IQR 0.66.1.10) | 0.998 | 1.16–1.42 |
| LDL (mmol/L) media (P–P) | 4.08 (IQR 2.17, 6.14) | 4.54 (IQR 2.93, 8.58) | 0.437 | --- |
| NHDL (mmol/L) media (P–P) | 9.89 (IQR 7.54, 13.31) | 10.34 (IQR 8.15, 14.83) | 0.339 | --- |
| ApoA (g/L)media (P–P) | 0.86 (IQR 0.71, 1.10) | 0.76 (IQR 0.53, 1.00) | 0.009 | 1–1.16 |
| ApoB (g/L)media (P–P) | 0.60 (IQR 0.36, 0.91) | 0.31 (IQR 0.21, 0.69) | 0.000 | 0.6–1.1 |
| ApoE (mg/mL) media (P–P) | 115.59 (IQR 19.91, 229.01) | 134.28 (IQR 16.58, 223.55) | 0.666 | 2.7–4.9 |
| LP(a) (mg/L) media (P–P) | 11.75 (IQR 3.93, 42.43) | 26.48 (IQR 9.46, 40.69) | 0.108 | 0–300 |
| GLU (mg/L) media (P–P) | 11.33 (IQR 7.41, 15.31) | 12.25 (IQR 8.86, 18.03) | 0.153 | 3.9–6.1 |
| AMS(U/L)media (P–P) | 124.95 (IQR 66.97, 208.59) | 420.10 ( (IQR 149.25, 852.78) | 0.000 | 17–115 |
| LIP(U/L)media (P–P) | 295.40 (IQR 141.36, 1219.60) | 840.42 (IQR 99.20, 2886.68) | 0.232 | 13–60 |
| MAP – mild acute pancreatitis; MSAP – moderately severe acute pancreatitis; SAP – severe acute pancreatitis; y – years; h – hours; IQR – inter-quartile range; X±s – mean value±standard deviation; WBC – white blood cell; PLT – white blood cell; HCT – hematocrit; NEUT – absolute value of neutrophils; LYM – absolute value of lymphocytes; NLR – ratio of neutrophils to lymphocytes; TP – total protein; ALB – albumin; TBIL – total bilirubin; DBIL – direct bilirubin; IBIL, indirect bilirubin; ALT – alanine aminotransferase; AST – aspartate aminotransferase; ALP – alkaline phosphatase; UREA – urea nitrogen; Cre, creatinine; Na – blood sodium (Na); Ca – blood calcium (Ca); TC – total cholesterol; TG – total glyceride; HDL – high-density lipoprotein; LDL – low-density lipoprotein; NHDL – non-high-density lipoprotein; ApoA – apolipoprotein A; ApoB – apolipoprotein B; ApoE – apolipoprotein E; LPa – lipoprotein a; GLU – blood glucose; AMS – amylase; LIP – lipase. | ||||