10 February 2024 : Database Analysis
Association Between Albumin-Corrected Anion Gap and In-Hospital Mortality and Sepsis-Associated Acute Kidney Injury
Haixu Guo12BCDEF, Jie Wang13A*DOI: 10.12659/MSM.943012
Med Sci Monit 2024; 30:e943012
Table 1 Baseline characteristics of the study population.
| Characteristics | Death (n=1909) | Survival (n=5591) | p |
|---|---|---|---|
| 68.7 (57.3–80.1) | 63.6 (51.4–74.0) | <0.001 | |
| 1082 (56.7) | 3223 (57.8) | 0.461 | |
| 0.539 | |||
| White | 765 (40.1) | 2196 (39.3) | |
| Others | 1144 (59.9) | 3395 (60.7) | |
| 6.9 (2.9–13.1) | 14.2 (8.8–22.9) | <0.001 | |
| 5.3 (2.6–10.6) | 6.4 (3.5–11.6) | 0.046 | |
| Hypertension | 629 (32.9) | 5591 (36.8) | 0.003 |
| Diabetes | 539 (28.2) | 1796 (32.1) | 0.002 |
| Chronic pulmonary disease | 497 (26.0) | 1433 (25.6) | 0.727 |
| Myocardial infarction | 392 (20.5) | 592 (10.6) | <0.001 |
| Hemoglobin, g/dL | 10.4 (8.8–12.1) | 10.7 (9.3–12.4) | <0.001 |
| Platelets, 10/L | 160.0 (97.0–232.0) | 183.4 (123.8–253.0) | <0.001 |
| White blood cell, 10/L | 14.5 (9.2–19.5) | 12.6 (9.0–17.1) | <0.001 |
| pH | 7.3 (7.2–7.4) | 7.4 (7.3–7.4) | <0.001 |
| Glucose, mmol/L | 148.5 (116.5–204.5) | 142.3 (115.5–183.5) | <0.001 |
| Calcium, mmol/L | 8.1 (7.5–8.7) | 8.1 (7.6–8.6) | <0.001 |
| Blood urea nitrogen, mmol/L | 33 (21.5–53) | 24.0 (15.0–40.0) | <0.001 |
| Creatinine, mg/dL | 1.7 (1.1–2.6) | 1.2 (0.8–2.0) | <0.001 |
| Sodium, mmol/L | 138.5 (135.0–142.5) | 138.5 (136.0–141.5) | 0.952 |
| Potassium, mmol/L | 4.4 (4.0–5.0) | 4.2 (3.9–4.8) | <0.001 |
| Chloride, mmol/L | 103.5 (98.0–108.0) | 104.5 (100.5–108.0) | 0.013 |
| Bicarbonate, mmol/L | 19.5 (15.5–23.0) | 21.5 (18.5–24.5) | <0.001 |
| Albumin, g/dL | 2.9 (2.4–3.4) | 3.1 (2.7–3.6) | <0.001 |
| Anion Gap, mmol/L | 17.5 (14.5–22) | 15.5 (13.0–18.0) | <0.001 |
| ACAG, mmol/L | 21.5 (18.3–25.8) | 18.3 (16.0–21.5) | <0.001 |
| Mean blood pressure, mmHg | 72.9 (67.6–79.7) | 76.0 (70.6–82.9) | <0.001 |
| Respiratory rate, cpm | 22.0 (19.1–25.1) | 20.0 (17.4–23.5) | <0.001 |
| Heart rate, bpm | 93.1 (80.0–106.6) | 89.8 (78.0–102.0) | <0.001 |
| 80.0 (66.7–98.3) | 84.0 (70.0–100.5) | <0.001 | |
| 168.0 (160.0–178) | 170.0 (163.0–178.0) | <0.001 | |
| 805.0 (245.0–1560.0) | 1364.0 (795.5–2250.0) | <0.001 | |
| 12.0 (9.0–15.0) | 9.0 (6.0–12.0) | <0.001 | |
| MV | 1276 (66.8) | 2901 (51.9) | <0.001 |
| RRT | 444 (23.3) | 632 (11.3) | <0.001 |
| LOS – length of stay; ICU – Intensive Care Unit; ACAG – albumin-corrected anion gap; SOFA – sequential organ failure assessment; MV – mechanical ventilation; RRT – renal replacement therapy. | |||