Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

04 May 2024: Database Analysis

Risk Factors of Age-Related Macular Degeneration in a Population-Based Study: Results from SHIP-TREND-1 (Study of Health in Pomerania-TREND-1)

Lisa Lüdtke 1BCDEF* , Till Ittermann 2CDE , Rico Großjohann 1CD , Clemens Jürgens 2DE , Henry Völzke 2ABEG , Frank Tost 1ADE , Andreas Stahl 1DE

DOI: 10.12659/MSM.943140

Med Sci Monit 2024; 30:e943140

Table 2 Association of potential risk factors with AMD.

TotalOR (95%-CI)MalesOR (95%-CI)FemalesOR (95%-CI)
Age; years# 1.04 (1.03; 1.06)* 1.05 (1.03; 1.07)* 1.03 (1.01;1.05)*
Educational years# 0.92 (0.85; 1.00)0.80 (0.71; 0.92)* 1.02 (0.89; 1.16)
Smoking status
 Former vs never1.00 (0.65; 1.52)2.52 (1.25; 5.07)* 0.51 (0.27; 0.95)*
 Current vs never0.85 (0.48; 1.51)3.09 (1.32; 7.21)* 0.32 (0.13; 0.78)*
Physical activity1.02 (0.67; 1.55)0.67 (0.38; 1.20)1.55 (0.83; 2.88)
Body mass index; kg/m1.00 (0.96; 1.05)1.07 (1.01; 1.14)* 0.95 (0.90; 1.01)
Body height; cm1.00 (0.98; 1.02)0.98 (0.95; 1.02)1.02 (0.97; 1.07)
Waist circumference; cm1.00 (0.99; 1.02)1.02 (0.99; 1.05)0.99 (0.97; 1.01)
Hip circumference; cm1.00 (0.98; 1.02)1.03 (0.99; 1.06)0.99 (0.97; 1.01)
Waist-to-hip-ratio0.86 (0.79; 9.35)1.36 (0.01; 426.7)0.14 (0.01; 16.2)
Waist-to-height-ratio1.29 (0.64; 25.5)51.1 (0.51; 5138)0.12 (0.01; 3.85)
Waist-to-weight-ratio1.42 (0.17; 7.51)0.21 (0.01; 7.62)3.21 (0.34; 30.3)
HbA1c; %1.24 (0.90; 1.71)1.35 (0.90; 2.01)1.03 (0.61; 1.73)
Type 2 diabetes1.41 (0.75; 2.63)0.94 (0.37; 2.38)1.97 (0.86; 4.50)
Total cholesterol; mmol/L0.99 (0.83; 1.17)1.05 (0.82; 1.35)0.98 (0.78; 1.22)
LDL-cholesterol; mmol/L0.84 (0.68; 1.03)0.96 (0.71; 1.28)0.78 (0.59; 1.03)
HDL-cholesterol; mmol/L# 1.33 (0.83; 2.15)0.57 (0.24; 1.35)2.52 (1.36; 4.70)*
Triglycerides; mmol/L1.12 (0.96; 1.29)1.17 (0.95; 1.44)0.80 (0.56; 1.15)
Hypertension1.21 (0.79; 1.84)1.55 (0.80; 3.00)0.95 (0.55; 1.61)
High-sensitive C-reactive protein; mg/L0.96 (0.89; 1.03)0.93 (0.85; 1.02)0.98 (0.88; 1.08)
Ferritin; μg/L1.00 (0.99; 1.00)1.00 (0.99; 1.00)1.00 (0.99; 1.00)
Thyroid-stimulating hormone; mIU/L0.97 (0.81; 1.15)1.04 (0.78; 1.40)0.92 (0.72; 1.17)
Free triiodothyronine; pmol/L# 1.14 (0.95; 1.39)1.08 (0.92; 1.27)1.53 (1.02; 2.28)*
Free thyroxin; pmol/L1.00 (0.94; 1.07)0.92 (0.79; 1.07)1.06 (0.98; 1.15)
Data are reported as odds ratios (OR) and 95% confidence intervals (CI) derived from logistic regression models with AMD as outcome and the respective potential risk factor as exposure adjusted for age and weighted for drop-out of participants because of non-readable fundus images.
* p
# for these markers we observed non-linear associations, which are illustrated in . In this Table the linear associations (without transformation of the exposure variable) are reported, which may differ in terms of significance to those in .

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750