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04 May 2024: Database Analysis

Risk Factors of Age-Related Macular Degeneration in a Population-Based Study: Results from SHIP-TREND-1 (Study of Health in Pomerania-TREND-1)

Lisa Lüdtke 1BCDEF* , Till Ittermann 2CDE , Rico Großjohann 1CD , Clemens Jürgens 2DE , Henry Völzke 2ABEG , Frank Tost 1ADE , Andreas Stahl 1DE

DOI: 10.12659/MSM.943140

Med Sci Monit 2024; 30:e943140

Table 3 Comparison of subjects with and without gradable fundus images in the SHIP-TREND-1 cohort.

VariableGradeable fundus imagep*
No (n=1089)Yes (n=1418)
Age; years64 (53; 74)52 (43; 62)
Females48.5%54.0%0.007
Educational years12 (11; 15)13 (11; 15)0.494
Smoking status0.617
 Never34.1%35.7%
 Former45.9%45.6%
 Current20.0%18.7%
Physical activity69.5%70.4%0.622
Body mass index; kg/m27.9 (25.1; 31.3)27.0 (24.2; 30.2)0.001
Waist circumference; cm98 (89; 108)94 (84; 104)
HbA1c; %5.6 (5.4; 6.00)5.5 (5.3; 5.7)
Type 2 diabetes14.1%6.4%
Total cholesterol; mmol/L5.4 (4.5; 6.1)5.3 (4.6; 6.1)0.980
Low-density lipoprotein cholesterol; mmol/L3.3 (2.6; 4.0)3.3 (2.7; 3.9)0.330
High-density lipoprotein cholesterol; mmol/L1.44 (1.17; 1.75)1.46 (1.21; 1.78)0.301
Triglycerides; mmol/L1.41 (0.94; 2.04)1.17 (0.82; 1.76)
Hypertension58.8%38.6%
High-sensitive C-reactive protein; mg/L1.27 (0.67; 2.90)1.11 (0.57; 2.35)0.001
Ferritin; μg/L102 (53; 191)86 (42; 170)0.002
Thyroid-stimulating hormone; mIU/L1.27 (0.86; 1.75)1.27 (0.90; 1.80)0.943
Free triiodothyronine; pmol/L4.5 (4.1; 4.8)4.5 (4.2; 4.9)0.006
Free thyroxin; pmol/L13.0 (11.9; 14.3)12.9 (11.8; 14.0)0.183
Data are reported as median, 25 and 75 percentile for continuous variables or as percentage for categorical data;
* p-values were derived from Mann-Whitney-U test for continuous data or from χ-tests for categorical data.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750