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16 February 2024: Clinical Research

Factors Influencing Discontinuation of Clazosentan Therapy in Elderly Patients with Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study from a Japanese Single Center

Tatsushi Mutoh 1ABCDEF* , Hiroaki Aono 1BDE , Wataru Seto 2BE , Takehiro Kimoto 2BE , Ryota Tochinai 3DE , Junta Moroi 1BE , Tatsuya Ishikawa 1DE

DOI: 10.12659/MSM.943303

Med Sci Monit 2024; 30:e943303

Table 1 Univariate analysis of general clinical data for clazosentan therapy between completed and discontinued groups among 40 postoperative SAH patients.

Treatment of clazosentanP
Completed (n=31)Discontinued (n=9)
Age (y)60.5 (12.6)67.7 (14.0)0.39
Age of 75 years and older3 (9)4 (44)
Women24 (77)7 (78)0.67
Body weight (kg)60.9 (13.1)58.8 (11.5)0.13
WFNS grade2.2 (1.5)2.2 (1.7)0.58
Location of aneurysms0.46
 Anterior circulation28 (90)9 (100)
 Posterior circulation3 (10)0 (0)
 Surgical clipping21 (68)7 (78)0.44
 Endovascular coiling10 (32)2 (22)
Duration of drug therapy13.1 (1.6)4.7 (2.4)
eGFR (mL/min/1.73 m)
 On admission80.0 (25.5)85,5 (24.1)10.36
 At peak80.4 (33.9)107.2 (32.3)0.06
BNP (pg/mL)
 On admission36.6 (22.7)73.5 (74.2)0.72
 At peak119.6 (98.2)77.0 (58.7)0.06
Peak urine volume
 24-h volume (mL/d)2,135 (730)1,285 (354)
 Volume per hour (mL/kg/h)1.35 (0.83)0.95 (0.31)
 Day-to-day variance (mL/kg/h)−0.52 (0.54)−0.96 (0.49)
Daily fluid balance (mL/d)1,987 (781)2,068 (878)0.81
Weight gain (kg)2.5 (1.9)3.2 (1.8)0.12
Vasospasm8 (26)4 (44)0.25
DCI4 (12)2 (22)0.41
Data are shown as mean±SD (range) or number (percentage). Statistically significant results at

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750