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16 February 2024: Clinical Research

Factors Influencing Discontinuation of Clazosentan Therapy in Elderly Patients with Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study from a Japanese Single Center

Tatsushi Mutoh 1ABCDEF* , Hiroaki Aono 1BDE , Wataru Seto 2BE , Takehiro Kimoto 2BE , Ryota Tochinai 3DE , Junta Moroi 1BE , Tatsuya Ishikawa 1DE

DOI: 10.12659/MSM.943303

Med Sci Monit 2024; 30:e943303

Table 2 Multivariate binary logistic regression analysis of predictors of discontinuation of the clazosentan therapy in 40 postoperative SAH patients.

VariablesOdds ratio (95% CI)P
Peak urine volume
 24-h volume (mL/d)0.997 (0.998–1.002)0.08
 Volume per hour (mL/kg/h)0.822 (0.242–2.787)0.75
 Day-to-day variance (mL/kg/h)0.015 (0.014–0.983)
Age of ≥75 years1.770 (1.065–92.001)
Statistically significant results at

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750