Factors Influencing Discontinuation of Clazosentan Therapy in Elderly Patients with Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study from a Japanese Single Center

Tatsushi Mutoh; Hiroaki Aono; Wataru Seto; Takehiro Kimoto; Ryota Tochinai; Junta Moroi; Tatsuya Ishikawa

doi:10.12659/MSM.943303

16 February 2024 : Clinical Research

Factors Influencing Discontinuation of Clazosentan Therapy in Elderly Patients with Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study from a Japanese Single Center

Tatsushi Mutoh

^1ABCDEF*, Hiroaki Aono^1BDE, Wataru Seto^2BE, Takehiro Kimoto^2BE, Ryota Tochinai^3DE, Junta Moroi^1BE, Tatsuya Ishikawa^1DE

DOI: 10.12659/MSM.943303

Med Sci Monit 2024; 30:e943303

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Table 2 Multivariate binary logistic regression analysis of predictors of discontinuation of the clazosentan therapy in 40 postoperative SAH patients.

Variables	Odds ratio (95% CI)	P

Peak urine volume
24-h volume (mL/d)	0.997 (0.998–1.002)	0.08
Volume per hour (mL/kg/h)	0.822 (0.242–2.787)	0.75
Day-to-day variance (mL/kg/h)	0.015 (0.014–0.983)

Age of ≥75 years	1.770 (1.065–92.001)
Statistically significant results at

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Factors Influencing Discontinuation of Clazosentan Therapy in Elderly Patients with Aneurysmal Subarachnoid Hemorrhage: A Retrospective Study from a Japanese Single Center

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