19 August 2024 : Clinical Research
Comparative Analysis of Complications Following Distal Resections for Neuroendocrine Tumors and Adenocarcinoma: Unveiling the Differences
Bartosz Molasy
12BCDEF, Patryk Zemła 1BCDEF*, Sławomir Mrowiec 3AEF, Piotr Czopek 3BE, Katarzyna Kuśnierz 3ABDEF
DOI: 10.12659/MSM.943307
Med Sci Monit 2024; 30:e943307
Table 1 Significance of difference in clinical parameters and complications between NET and adenocarcinoma.
| NET (n=77) | PDAC (n=54) | Significance (p-value) | Strength of correlation* | ||
|---|---|---|---|---|---|
| Age (median (IQR)) | 58 (45.5–65.0) | 68.5 (61.8–74.0) | <0.001 | 0.418 | |
| Male sex | 37 (48.1%) | 24 (44.4%) | 0.724 | 0.036 | |
| ASA-PS Scale | I | 5 (6.5%) | 0 (0.0%) | <0.001 | 0.357 |
| II | 57 (74.0%) | 27 (50.0%) | |||
| III | 15 (19.5%) | 27 (50.0%) | |||
| Histopathological diagnosis | G1 | 32 (41.6%) | 16 (29.6%) | <0.001 | 0.346 |
| G2 | 44 (57.1%) | 26 (48.1%) | |||
| G3 | 1 (1.3%) | 12 (22.2%) | |||
| PanIN | None | 26 (33.8%) | 8 (14.8%) | <0.001 | 0.608 |
| PanIN 1 | 46 (59.7%) | 13 (24.1%) | |||
| PanIN 1–2 | 2 (2.6%) | 2 (3.7%) | |||
| PanIN 1–3 | 3 (3.9%) | 31 (57.4%) | |||
| Adipose tissue infiltration | 44 (57.1%) | 42 (77.8%) | 0.016 | 0.214 | |
| Vascular invasion | 45 (58.4%) | 33 (61.1%) | 0.857 | 0.027 | |
| Perineural invasion | 33 (42.9%) | 36 (66.7%) | 0.008 | 0.235 | |
| Lymph nodes metastasis | 25 (32.5%) | 40 (74.1%) | <0.001 | 0.410 | |
| Distant metastases | 13 (16.9%) | 6 (11.1%) | 0.453 | −0.081 | |
| Wirsung diameter ≥3 mm | 7 (9.1%) | 12 (22.2%) | 0.045 | 0.184 | |
| Soft pancreas | 23 (29.9%) | 12 (22.2%) | 0.423 | −0.085 | |
| Pancreatic fistula | A or none | 62 (80.5%) | 51 (94.4%) | 0.044 | −0.214 |
| B | 10 (13.0%) | 3 (5.6%) | |||
| C | 5 (6.5%) | 0 (0.0%) | |||
| Fistula Risk Score | Low | 2 (2.6%) | 7 (13.0%) | <0.001 | −0.355 |
| Moderate | 53 (68.8%) | 43 (79.6%) | |||
| High | 22 (28.6%) | 2 (3.7%) | |||
| Clavien-Dindo | I | 47 (61.0%) | 17 (31.5%) | <0.001 | 0.376 |
| II | 14 (18.2%) | 25 (46.3%) | |||
| III | 12 (15.6%) | 12 (22.2%) | |||
| IV | 4 (5.2%) | 0 (0.0%) | |||
| NET – neuroendocrine tumors; PDAC – pancreatic ductal adenocarcinoma; IQR – interquartile range; ASA-PS – American Society of Anesthesiologists physical status classification system; PanIN – pancreatic intraepithelial neoplasia; * Negative correlation means that clinical parameters occur more frequently or have higher values in NET tumors; Positive correlation means that they occur more frequently or have high values in adenocarcinomas. | |||||