03 July 2024 : Clinical Research
Biochemical and Anthropometric Indices of Insulin Resistance in Obese and Overweight Children with Metabolic Dysfunction-Associated Fatty Liver Disease
Kinga Trochimczyk
1ABCDEF*, Marta Flisiak-Jackiewicz 1BCD, Anna Bobrus-Chociej 1BCD, Anna Lebensztejn1BCDEF, Małgorzata Wojtkowska 2BCD, Jacek Jamiołkowski 3ABCDE, Dariusz Marek Lebensztejn 1ACDEFG
DOI: 10.12659/MSM.943375
Med Sci Monit 2024; 30:e943375
Table 1 Comparison of selected clinical, biochemical parameters, and potential insulin resistance indices between the group of children diagnosed with metabolic disfunction-associated fatty liver disease and the control group.
| Parameter | MAFLD group (n=184)median (Q1–Q3) | Control group (n=80)median (Q1–Q3) | p |
|---|---|---|---|
| Age (years) | 12 (11–15) | 12 (10–15) | NS |
| Male, n (%) | 137 (74.5%) | 43 (53.8%) | <0.01 |
| BMI (kg/m) | 28.06 (25.70–32.50) | 28.93 (25.54–31.68) | NS |
| WC (cm) | 96 (90–105.75) | 93 (85.50–99.50) | 0.03 |
| HC (cm) | 101 (94–111.25) | 104 (95–112) | <0.01 |
| WHR | 0.95 (0.90–0.99) | 0.92 (0.86–0.97) | <0.01 |
| ALT (U/l) | 40 (26–64.75) | 20 (15–28.00) | <0.01 |
| AST (U/l) | 30 (24–40.75) | 22 (19–25.75) | <0.01 |
| GGTP (IU/l) | 23 (18–31) | 17 (14–22) | <0.01 |
| Bilirubin (mg/dl) | 0.53 (0.40–0.74) | 0.5 (0.36–0.74) | NS |
| Cholesterol (mg/dl) | 167 (144–189.75) | 152.5 (137.50–177.75) | 0.02 |
| HDL (mg/dl) | 45 (39–51) | 46.5 (40–56.75) | NS |
| LDL (mg/dl) | 98 (78–117.5) | 94 (76–110.75) | NS |
| TG (mg/dl) | 108 (80.25–153.75) | 85.5 (62.25–111) | <0.01 |
| Glucose (mg/dl) | 89 (84–94) | 89 (84–93) | NS |
| Insulin (μIU/ml) | 17.2 (12.6–22.68) | 14.85 (10.78–20.68) | NS |
| Uric acid (mg/dl) | 6 (5.12–6.94) | 5.6 (4.65–6.50) | 0.04 |
| HOMA-IR | 3.7 (2.72–5.10) | 3.3 (2.38–4.52) | NS |
| TyG | 8.5 (8.15–8.82) | 8.29 (7.89–8.54) | <0.01 |
| TyG-BMI | 240.14 (219.89–275.59) | 236.22 (212.52–268.09) | NS |
| TyG-WC | 789.05 (689.11–891.18) | 756.31 (623.71–814.58) | 0.01 |
| TG/HDL | 2.42 (1.62–3.77) | 1.75 (1.21–2.47) | <0.01 |
| ALT – alanine aminotransferase; AST – aspartate aminotransferase; BMI – body mass indexl GGTP – gamma-glutamyl transpeptidase; HC – hip circumference; HDL – high density lipoprotein; HOMA-IR – homoeostatic model assessment of insulin resistance; IR – insulin resistance; LDL – low density lipoprotein; MAFLD – metabolic disfunction-associated fatty liver disease; NS – nonsignificant; TG – triglycerides; TG/HDL – triglyceride to high-density lipoprotein cholesterol ratio; TyG – triglyceride-glucose index; TyG-BMI – TyG-body mass index; TyG-WC – TyG-waist circumference; WC – waist circumference; WHR – waist-to-hip ratio. | |||