28 June 2024 : Database Analysis
Systemic Immune-Inflammation Index (SII) as a Predictor of Short-Term Mortality Risk in Sepsis-Associated Acute Kidney Injury: A Retrospective Cohort Study
Jie Sun1ABCDEF, Ying Qi1ABCDE, Wenxin Wang1EF, Pengpeng Meng2E, Changjin Han2E, Bing Chen1ABCDEFG*DOI: 10.12659/MSM.943414
Med Sci Monit 2024; 30:e943414
Table 3 Multivariate Cox regression analysis for exploring the association of SII with 28-day mortality among patients with AKI.
| Variable | Crude model | Model 1 | Model 2 | Model 3 | Model 4 | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| HR 95CI | P value | HR 95CI | P value | HR 95CI | P value | HR 95CI | P value | HR 95CI | P value | |
| SII/1000 | 1.03 (1.02~1.04) | <0.001 | 1.03 (1.02~1.04) | <0.001 | 1.03 (1.02~1.04) | <0.001 | 1.02 (1.02~1.03) | <0.001 | 1.02 (1.01~1.03) | <0.001 |
| SII quartiles | ||||||||||
| Q1 | 1.24 (1.08~1.42) | 0.002 | 1.25 (1.09~1.44) | 0.001 | 1.19 (1.03~1.36) | 0.015 | 1.13 (0.99~1.3) | 0.076 | 1.15 (1~1.32) | 0.057 |
| Q2 | 1 | Ref | 1 | Ref | 1 | Ref | 1 | Ref | 1 | Ref |
| Q3 | 1.42 (1.24~1.62) | <0.001 | 1.4 (1.22~1.6) | <0.001 | 1.43 (1.25~1.64) | <0.001 | 1.32 (1.15~1.51) | <0.001 | 1.33 (1.16~1.52) | <0.001 |
| Q4 | 1.82 (1.6~2.07) | <0.001 | 1.77 (1.55~2.01) | <0.001 | 1.85 (1.62~2.1) | <0.001 | 1.57 (1.37~1.79) | <0.001 | 1.55 (1.36~1.77) | <0.001 |
| no other covariates were adjusted. Age, sex. Model 1 and myocardial infarction, congestive heart failure, COPD, diabetes, severe liver disease, hypertension, chronic kidney disease. Model 2 and heart rate, mean blood pressure, respiratory rate, temperature, SPO, hemoglobin, BUN, creatinine, serum glucose, serum lactate, bicarbonate, potassium. Model 3 and vasopressor, invasive ventilation, RRT, AKI stage, SOFA, SAPSII. | ||||||||||