28 June 2024 : Database Analysis
Systemic Immune-Inflammation Index (SII) as a Predictor of Short-Term Mortality Risk in Sepsis-Associated Acute Kidney Injury: A Retrospective Cohort Study
Jie Sun1ABCDEF, Ying Qi1ABCDE, Wenxin Wang1EF, Pengpeng Meng2E, Changjin Han2E, Bing Chen1ABCDEFG*DOI: 10.12659/MSM.943414
Med Sci Monit 2024; 30:e943414
Table 4 Subgroup analysis of the association between SII and 28-day mortality.
| Subgroup | n | Fully adjusted HR (95% CI) | P for interaction | |||
|---|---|---|---|---|---|---|
| Q1 | Q2 | Q3 | Q4 | |||
| Age (years) | 0.691 | |||||
| <65 | 3657 | 1.03 (0.83~1.27) | Ref | 1.28 (1.03~1.59) | 1.56 (1.26~1.94) | |
| ≥65 | 4199 | 1.27 (1.05~1.53) | Ref | 1.38 (1.16~1.65) | 1.58 (1.34~1.87) | |
| Gender | 0.436 | |||||
| Female | 3327 | 1.01 (0.81~1.25) | Ref | 1.2 (0.98~1.47) | 1.4 (1.15~1.71) | |
| Male | 4529 | 1.25 (1.04~1.51) | Ref | 1.41 (1.18~1.69) | 1.69 (1.41~2.01) | |
| SOFA score | 0.12 | |||||
| <6 | 6136 | 1.2 (1~1.43) | Ref | 1.37 (1.17~1.61) | 1.66 (1.43~1.94) | |
| ≥6 | 1720 | 1.01 (0.8~1.28) | Ref | 1.16 (0.9~1.5) | 1.23 (0.95~1.61) | |
| SAPS II | 0.087 | |||||
| <40 | 3171 | 0.85 (0.63~1.14) | Ref | 1.12 (0.85~1.47) | 1.27 (0.96~1.67) | |
| ≥40 | 4685 | 1.26 (1.07~1.48) | Ref | 1.37 (1.17~1.61) | 1.63 (1.4~1.9) | |
| Chronic kidney disease | 0.928 | |||||
| No | 5614 | 1.14 (0.96~1.35) | Ref | 1.37 (1.16~1.61) | 1.57 (1.34~1.85) | |
| Yes | 2242 | 1.14 (0.89~1.47) | Ref | 1.19 (0.94~1.51) | 1.44 (1.14~1.82) | |
| Congestive heart failure | 0.23 | |||||
| No | 4724 | 1.24 (1.04~1.49) | Ref | 1.49 (1.24~1.78) | 1.68 (1.41~2.01) | |
| Yes | 3132 | 1.06 (0.84~1.33) | Ref | 1.15 (0.94~1.41) | 1.37 (1.12~1.67) | |
| Myocardial infarction | 0.167 | |||||
| No | 6226 | 1.08 (0.92~1.26) | Ref | 1.32 (1.13~1.54) | 1.56 (1.34~1.81) | |
| Yes | 1630 | 1.51 (1.12~2.04) | Ref | 1.37 (1.03~1.82) | 1.54 (1.17~2.03) | |
| Diabetes mellitus | 0.25 | |||||
| No | 5139 | 1.05 (0.88~1.24) | Ref | 1.3 (1.1~1.53) | 1.44 (1.22~1.69) | |
| Yes | 2717 | 1.39 (1.09~1.78) | Ref | 1.4 (1.1~1.77) | 1.8 (1.42~2.28) | |
| Hypertension | 0.108 | |||||
| No | 3488 | 1.06 (0.88~1.28) | Ref | 1.13 (0.94~1.36) | 1.39 (1.16~1.67) | |
| Yes | 4368 | 1.25 (1.02~1.55) | Ref | 1.57 (1.29~1.91) | 1.75 (1.44~2.13) | |
| Malignant cancer | 0.147 | |||||
| No | 6724 | 1.01 (0.86~1.19) | Ref | 1.33 (1.15~1.54) | 1.52 (1.31~1.76) | |
| Yes | 1132 | 1.34 (0.98~1.83) | Ref | 1.11 (0.79~1.55) | 1.42 (1.04~1.94) | |