29 January 2024: Review Articles
From Liver to Brain: How MAFLD/MASLD Impacts Cognitive Function
David Medina-Julio 12AEF , Mariana M. Ramírez-Mejía 34EF , Jacqueline Cordova-Gallardo 25AEF , Emilio Peniche-Luna 6EF , Carlos Cantú-Brito 27AF , Nahum Mendez-Sanchez 23AEF*DOI: 10.12659/MSM.943417
Med Sci Monit 2024; 30:e943417
Table 1 Insights from studies MAFLD/MASLD and cognitive impairment.
| Author | Study design | Group | Purpose | Measuring instrument for cognitive impairment | Results |
|---|---|---|---|---|---|
| Elliott et al (2013) []12 | Cohort | 224 NAFLD100 controls | To assess functional physical capacity and cognitive abilities | Psychological Health Assessment Questionnaire (PHAQ) y Cognitive Failures Questionnaire (CFQ) | NAFLD patients: |
| Seo et al (2016) []13 | Cross sectional | 4472 participants from 20 to 59 years old | To evaluate liver enzyme activity and cognitive assessment | SRRTSDLTSDST | NAFLD patients: |
| Tuttolomondo et al (2018) []14 | Case-control | 80 NAFLD83 without liver or cardiovascular disease | To assess cognitive performance in patients with NAFLD | MMSE (74 with MAFL y 65 controls) | NAFLD patients: |
| Weinstein et al (2019) []10 | Cross sectional | 1287 participants378 (29%) with NAFLD | To assess the relationship of NAFLD and its severity, using the NAFLD Fibrosis Score (NFS) with cognitive performance. | Trail – making testAbstract reasoning testsHooper’s Visual Organization Test (visual perception) | NAFLD and cognitive performance were not associated; however patients with poorer cognitive performance on tests were associated with higher risk of advanced fibrosis in patients with NAFLD (β=-0.11±0.05; P=0.028) |
| Moretti et al (2019) []15 | Cross sectional | 671 NAFLD687 controls | To assess the relationship between NAFLD and performance with frontal, executive functions, behavior changes (mood, apathy, and anxiety) | FAB Test (Frontal Assessment Battery)Becks testHAM-A testAES-C | NAFLD patients: |
| Celikbilek et al (2018) []16 | Cross sectional | 70 NAFLD and 73 controls matched by age and sex from 18 to 70 years | To assess cognitive functions | Turkish version of the MoCa test | NAFLD patients: |
| AES-C – Apathy Evaluation Scale – Clinician Version; CFQ: Cognitive Failures Questionnaire; FAB Test – Frontal Assessment Battery Test; HAM-A Test – Hamilton Anxiety Rating Scale; MAFLD – metabolic dysfunction-associated fatty liver disease; MMSE – mini-mental state examination; MoCA – Montreal Cognitive Assessment; NAFLD – non-alcoholic fatty liver disease, NFS – NAFLD fibrosis score; PHAQ – Psychological Health Assessment Questionnaire; SDLT – Stroop Color and Word Test – Delayed Recall; SDST – Stroop Color and Word Test – Sustained Attention; SRRT – Symbol Digit Modalities Test. | |||||