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29 January 2024 : Review article  

From Liver to Brain: How MAFLD/MASLD Impacts Cognitive Function

David Medina-Julio12AEF, Mariana M. Ramírez-Mejía34EF, Jacqueline Cordova-Gallardo25AEF, Emilio Peniche-Luna ORCID logo6EF, Carlos Cantú-Brito27AF, Nahum Méndez-Sánchez ORCID logo23AEF*

DOI: 10.12659/MSM.943417

Med Sci Monit 2024; 30:e943417

Table 1 Insights from studies MAFLD/MASLD and cognitive impairment.

AuthorStudy designGroupPurposeMeasuring instrument for cognitive impairmentResults
Elliott et al (2013) []12 Cohort224 NAFLD100 controlsTo assess functional physical capacity and cognitive abilitiesPsychological Health Assessment Questionnaire (PHAQ) y Cognitive Failures Questionnaire (CFQ)NAFLD patients:
Seo et al (2016) []13 Cross sectional4472 participants from 20 to 59 years oldTo evaluate liver enzyme activity and cognitive assessmentSRRTSDLTSDSTNAFLD patients:
Tuttolomondo et al (2018) []14 Case-control80 NAFLD83 without liver or cardiovascular diseaseTo assess cognitive performance in patients with NAFLDMMSE (74 with MAFL y 65 controls)NAFLD patients:
Weinstein et al (2019) []10 Cross sectional1287 participants378 (29%) with NAFLDTo assess the relationship of NAFLD and its severity, using the NAFLD Fibrosis Score (NFS) with cognitive performance.Trail – making testAbstract reasoning testsHooper’s Visual Organization Test (visual perception)NAFLD and cognitive performance were not associated; however patients with poorer cognitive performance on tests were associated with higher risk of advanced fibrosis in patients with NAFLD (β=-0.11±0.05; P=0.028)
Moretti et al (2019) []15 Cross sectional671 NAFLD687 controlsTo assess the relationship between NAFLD and performance with frontal, executive functions, behavior changes (mood, apathy, and anxiety)FAB Test (Frontal Assessment Battery)Becks testHAM-A testAES-CNAFLD patients:
Celikbilek et al (2018) []16 Cross sectional70 NAFLD and 73 controls matched by age and sex from 18 to 70 yearsTo assess cognitive functionsTurkish version of the MoCa testNAFLD patients:
AES-C – Apathy Evaluation Scale – Clinician Version; CFQ: Cognitive Failures Questionnaire; FAB Test – Frontal Assessment Battery Test; HAM-A Test – Hamilton Anxiety Rating Scale; MAFLD – metabolic dysfunction-associated fatty liver disease; MMSE – mini-mental state examination; MoCA – Montreal Cognitive Assessment; NAFLD – non-alcoholic fatty liver disease, NFS – NAFLD fibrosis score; PHAQ – Psychological Health Assessment Questionnaire; SDLT – Stroop Color and Word Test – Delayed Recall; SDST – Stroop Color and Word Test – Sustained Attention; SRRT – Symbol Digit Modalities Test.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750