Effect of Nasal Continuous Positive Airway Pressure on Retinopathy of Prematurity in Preterm Newborns: A Comparative Analysis with Mechanical Ventilation and High-Flow Nasal Cannula Therapy

Daniela M. Cioboata; Aniko M. Manea; Oana C. Costescu; Florina M. Doandes; Timea E. Brandibur; Nicoleta Lungu; Mihai Dinu; Florina Stoica; Radu E. Iacob; Marioara Boia

doi:10.12659/MSM.943486

13 April 2024 : Clinical Research

Effect of Nasal Continuous Positive Airway Pressure on Retinopathy of Prematurity in Preterm Newborns: A Comparative Analysis with Mechanical Ventilation and High-Flow Nasal Cannula Therapy

Daniela M. Cioboata^12ABDG, Aniko M. Manea^12BDE*, Oana C. Costescu^12AC, Florina M. Doandes^12DF, Timea E. Brandibur^12BF, Nicoleta Lungu^12A, Mihai Dinu^3C, Florina Stoica^4A, Radu E. Iacob^5B, Marioara Boia^12ADE

DOI: 10.12659/MSM.943486

Med Sci Monit 2024; 30:e943486

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Table 1 Univariate binary logistic regression analysis results showing the associations between different interventions or perinatal characteristics and ROP at 21 days of life.

Characteristics	OR (95% CI)	P value	ROP Incidence rate*
Sex, Male/Female	2.159 (1.063–4.383)	<0.05	63.51%/47.62%
GA	0.758 (0.651–0.883)	<0.001
BW	0.998 (0.997–0.999)	<0.001
Apgar score at 1 min	0.685 (0.564–0.833)	<0.001
Apgar score at 5 min	0.598 (0.451–0.793)	<0.001
Hb at 1 day of life	0.808 (0.690–0.946)	<0.01
HCT at 1 day of life	0.939 (0.889–0.991)	<0.05
RBC count at 1 day of life	0.472 (0.258–0.863)	<0.05
Transfusions, yes/no	5.250 (2.465–11.182)	<0.001	75.00%/36.36%
Gemellar pregnancy, yes/no	0.624 (0.256–1.521)	0.300	45.83%/57.55%
MV (SIPPV/SIMV) therapy, yes/no	1.942 (0.948–3.978)	0.070	64.81%/48.68%
nCPAP therapy, yes/no	4.267 (2.031–8.963)	<0.001	73.02%/38.81%
HFNC therapy, yes/no	1.314 (0.524–3.297)	0.560	60.87%/54.21%
ORs are displayed as crude values and include only the first subcategory in the cases of sex, transfusion, gemellar pregnancy, MV, nCPAP, and HFNC; all as dichotomous variables. ^* Incidence rate of ROP among neonates if their sex was male/female, if the pregnancy was gemellar/non-gemellar, and if they underwent/did not undergo transfusions, MV, nCPAP, and HFNC. ROP – retinopathy of prematurity; OR – odds ratio; GA – gestational age; BW – birth weight; Hb – hemoglobin; HCT – hematocrit; RBC – red blood cell; MV – mechanical ventilation; SIPPV – synchronized intermittent positive pressure ventilation; SIMV – synchronized intermittent mandatory ventilation; nCPAP – nasal continuous positive airway pressure; HFNC – high-flow nasal cannula.

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Effect of Nasal Continuous Positive Airway Pressure on Retinopathy of Prematurity in Preterm Newborns: A Comparative Analysis with Mechanical Ventilation and High-Flow Nasal Cannula Therapy

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