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06 May 2024 : Clinical Research  

Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury After Massive Burns

Wojciech Klimm ORCID logo1ABCDEFG*, Katarzyna Szamotulska ORCID logo2ABCDEF, Marek Karwański ORCID logo3CDE, Zbigniew Bartoszewicz4ABCDE, Wojciech Witkowski5ABCDE, Tomasz Rozmyslowicz6DEF, Stanisław Niemczyk ORCID logo1ABCDEFG

DOI: 10.12659/MSM.943500

Med Sci Monit 2024; 30:e943500

Table 1 Characteristics of the studied group of patients.

CharacteristicsN=33
Sex (M/F)22/11
Age (years), mean (±SD)48 (±18.58)
BMI (kg/m), mean (±SD)25.77 (±5.42)
TBSA (m), mean (±SD)1.89 (±0.25)
Burned TBSA (%), mean (±SD)42.21 (±18.14)
3 degree burns, n (%)22 (66.66)
TBSA with 3 degree burns (m), mean(±SD)12.36 (±7.27)
Respiratory tract burns, n (%)23 (69.7)
Consciousness disturbances (GCS), n (%)
 None or mild (13–15 pts)8 (24,24)
 Moderate (9–12 pts)0
 Severe or intubation (<8 pts)25 (75,76)
ABSI score (pts), mean (±SD)5.82 (±2.2)
APACHE II score (pts), mean (±SD)15.27 (±8.13)
Patients with AKI-positive status, n (%)15 (45.5)
AKI-positive status in RIFLE classification
 Risk, n (% active AKI-positive)14 (93.33)
 Injury, n (% AKI-positive)13 (86.67)
 Failure, n (% AKI-positive)10 (66.67)
Requirement of renal replacement therapy, n (% AKI-positive)5 (33,33)
Administration of pressor amines, n (%)22 (66.67)
Death/survival, n (%)16 (48.48)/17 (51.52)
SD – standard deviation; BMI – body mass index; TBSA – total body surface area; GCS – Glasgow coma scale; ABSI – Abbreviated Burn Severity Index; AKI – acute kidney injury; RIFLE – Risk, Injury, Failure, Loss-of-function, End-stage classification; n – number of patients.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750