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06 May 2024 : Clinical Research  

Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury After Massive Burns

Wojciech Klimm ORCID logo1ABCDEFG*, Katarzyna Szamotulska ORCID logo2ABCDEF, Marek Karwański ORCID logo3CDE, Zbigniew Bartoszewicz4ABCDE, Wojciech Witkowski5ABCDE, Tomasz Rozmyslowicz6DEF, Stanisław Niemczyk ORCID logo1ABCDEFG

DOI: 10.12659/MSM.943500

Med Sci Monit 2024; 30:e943500

Table 2 TIMP-1-4 concentration values (ng/mL) obtained during the observation period.

Days from injuryAKI-positive statusAKI-negative statusAKI vs Non-AKI status p-valueReference value (min–max)
nMedian (min–max)P value*nMedian (min–max)P value*
sTIMP-117451.99 (227.29–570.99)0.0161132.75145.56 (117.52–185.4)
26433.95 (216.66–594.06)0.03110209.67 (125.61–346.79)0.0200.005
35238.75 (195.08–407.84)0.06319188.78 (124.36–664.34)<0.0010.008
41224.4514186.57 (148.69–358.54)<0.001
51197.857169.96 (160.39–193.88)0.016
uTIMP-117443.95 (9.18–585.14)0.01619.786.47 (0.49–13.54)
2631.24 (3.69–162.17)0.0941023.68 (2.87–138.7)0.0200.792
3715.1 (8.76–86.19)0.016195.38 (1.46–86.26)0.7600.018
4322.87 (17.27–30.72)0.2501511.7 (2.11–54.11)0.0100.250
5329.05 (5.68–38.90)0.500715.94 (3.35–47.32)0.1090.667
sTIMP-217100.61 (93.47–126.72)0.375181.17113.16 (102.67–134.34)
26109.40 (82.65–117.87)0.31310101.69 (75.17–118.41)0.0650.492
3699.44 (62.99–122.25)0.1561991.72 (69.96–156.35)0.0010.780
4293.66 (84.25–103.07)0.5001494.45 (74.31–118.95)0.0010.600
5287.94 (75.03–100.84)0.500785.50 (74.6–105.51)0.0161.000
uTIMP-21795.73 (17.63–936.83)0.031158.2829.97 (0.38–76.66)
2640.40 (14.03–150.33)0.3131048.43 (14.51–100.27)0.0370.875
3751.32 (19.32–2844.14)0.1091924.83 (9.07–1719.38)0.6230.063
4338.71 (34.39–88.45)0.2501531.23 (6.13–61.32)0.9340.164
5339.54 (26.29–71.08)0.500732.11 (4.02–65.12)0.9340.667
sTIMP-31750.40 (42.52–74.07)0.016123.6333.78 (23.63–83.03)
2654.03 (33.78–64.49)0.0631040.40 (17.59–54.1)0.1720.048
3746.55 (23.63–77.11)0.2031938.28 (23.63–61.13)0.1820.412
4346.55 (46.55–67.76)0.2501440.40 (28.94–61.13)0.0410.115
5350.4 (46.55–57.67)0.250733.78 (28.94–38.28)0.6250.008
sTIMP-4173.38 (1.82–5.51)0.03111.241.91 (1.33–2.29)
262.86 (2.14–4.73)0.031101.75 (1.24–3.1)0.2640.004
372.33 (1.47–7.72)0.109191.72 (1.01–4.51)0.8520.065
433.32 (2.42–3.81)0.250142.03 (1.33–3.76)0.5420.068
532.88 (1.82–3.24)0.50071.98 (8.23–3.28)0.9380.383
() comparison with the reference value. TIMP 1–4 – tissue inhibitor of metalloproteinases 1–4; s – blood serum; u, urine; AKI – acute kidney injury; n – number of observations.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750