06 May 2024 : Clinical Research
Tissue Inhibitors of Metalloproteinase 1 (TIMP-1) and 3 (TIMP-3) as New Markers of Acute Kidney Injury After Massive Burns
Wojciech Klimm



DOI: 10.12659/MSM.943500
Med Sci Monit 2024; 30:e943500
Table 2 TIMP-1-4 concentration values (ng/mL) obtained during the observation period.
Days from injury | AKI-positive status | AKI-negative status | AKI vs Non-AKI status p-value | Reference value (min–max) | |||||
---|---|---|---|---|---|---|---|---|---|
n | Median (min–max) | P value* | n | Median (min–max) | P value* | ||||
sTIMP-1 | 1 | 7 | 451.99 (227.29–570.99) | 0.016 | 1 | 132.75 | – | – | 145.56 (117.52–185.4) |
2 | 6 | 433.95 (216.66–594.06) | 0.031 | 10 | 209.67 (125.61–346.79) | 0.020 | 0.005 | ||
3 | 5 | 238.75 (195.08–407.84) | 0.063 | 19 | 188.78 (124.36–664.34) | <0.001 | 0.008 | ||
4 | 1 | 224.45 | – | 14 | 186.57 (148.69–358.54) | <0.001 | – | ||
5 | 1 | 197.85 | – | 7 | 169.96 (160.39–193.88) | 0.016 | – | ||
uTIMP-1 | 1 | 7 | 443.95 (9.18–585.14) | 0.016 | 1 | 9.78 | – | – | 6.47 (0.49–13.54) |
2 | 6 | 31.24 (3.69–162.17) | 0.094 | 10 | 23.68 (2.87–138.7) | 0.020 | 0.792 | ||
3 | 7 | 15.1 (8.76–86.19) | 0.016 | 19 | 5.38 (1.46–86.26) | 0.760 | 0.018 | ||
4 | 3 | 22.87 (17.27–30.72) | 0.250 | 15 | 11.7 (2.11–54.11) | 0.010 | 0.250 | ||
5 | 3 | 29.05 (5.68–38.90) | 0.500 | 7 | 15.94 (3.35–47.32) | 0.109 | 0.667 | ||
sTIMP-2 | 1 | 7 | 100.61 (93.47–126.72) | 0.375 | 1 | 81.17 | – | – | 113.16 (102.67–134.34) |
2 | 6 | 109.40 (82.65–117.87) | 0.313 | 10 | 101.69 (75.17–118.41) | 0.065 | 0.492 | ||
3 | 6 | 99.44 (62.99–122.25) | 0.156 | 19 | 91.72 (69.96–156.35) | 0.001 | 0.780 | ||
4 | 2 | 93.66 (84.25–103.07) | 0.500 | 14 | 94.45 (74.31–118.95) | 0.001 | 0.600 | ||
5 | 2 | 87.94 (75.03–100.84) | 0.500 | 7 | 85.50 (74.6–105.51) | 0.016 | 1.000 | ||
uTIMP-2 | 1 | 7 | 95.73 (17.63–936.83) | 0.031 | 1 | 58.28 | – | – | 29.97 (0.38–76.66) |
2 | 6 | 40.40 (14.03–150.33) | 0.313 | 10 | 48.43 (14.51–100.27) | 0.037 | 0.875 | ||
3 | 7 | 51.32 (19.32–2844.14) | 0.109 | 19 | 24.83 (9.07–1719.38) | 0.623 | 0.063 | ||
4 | 3 | 38.71 (34.39–88.45) | 0.250 | 15 | 31.23 (6.13–61.32) | 0.934 | 0.164 | ||
5 | 3 | 39.54 (26.29–71.08) | 0.500 | 7 | 32.11 (4.02–65.12) | 0.934 | 0.667 | ||
sTIMP-3 | 1 | 7 | 50.40 (42.52–74.07) | 0.016 | 1 | 23.63 | – | – | 33.78 (23.63–83.03) |
2 | 6 | 54.03 (33.78–64.49) | 0.063 | 10 | 40.40 (17.59–54.1) | 0.172 | 0.048 | ||
3 | 7 | 46.55 (23.63–77.11) | 0.203 | 19 | 38.28 (23.63–61.13) | 0.182 | 0.412 | ||
4 | 3 | 46.55 (46.55–67.76) | 0.250 | 14 | 40.40 (28.94–61.13) | 0.041 | 0.115 | ||
5 | 3 | 50.4 (46.55–57.67) | 0.250 | 7 | 33.78 (28.94–38.28) | 0.625 | 0.008 | ||
sTIMP-4 | 1 | 7 | 3.38 (1.82–5.51) | 0.031 | 1 | 1.24 | – | – | 1.91 (1.33–2.29) |
2 | 6 | 2.86 (2.14–4.73) | 0.031 | 10 | 1.75 (1.24–3.1) | 0.264 | 0.004 | ||
3 | 7 | 2.33 (1.47–7.72) | 0.109 | 19 | 1.72 (1.01–4.51) | 0.852 | 0.065 | ||
4 | 3 | 3.32 (2.42–3.81) | 0.250 | 14 | 2.03 (1.33–3.76) | 0.542 | 0.068 | ||
5 | 3 | 2.88 (1.82–3.24) | 0.500 | 7 | 1.98 (8.23–3.28) | 0.938 | 0.383 | ||
() comparison with the reference value. TIMP 1–4 – tissue inhibitor of metalloproteinases 1–4; s – blood serum; u, urine; AKI – acute kidney injury; n – number of observations. |