05 June 2024 : Review article
Advancements and Emerging Therapies in the Medical Management of Uterine Fibroids: A Comprehensive Scoping Review
Jarosław Krzyżanowski
1ABCDEF*, Tomasz Paszkowski 1ADE, Piotr Szkodziak 1DE, Sławomir Woźniak 1ADEF
DOI: 10.12659/MSM.943614
Med Sci Monit 2024; 30:e943614
Table 2 Emerging and alternative treatment options for uterine fibroids.
| Treatment option | References | Current state of the art | Limitations | Future scope |
|---|---|---|---|---|
| Vitamin D | Ciavattini 2016;Krzyzanowski 2023;Markowska 2012 | Inverse correlation between Vitamin D levels and UFPossible preventive effect | Limited dataData mainly on African-American women | Randomized trials on different races and in combined therapies |
| Green tea | Krzyzanowski 2023 | Increased quality of lifePossibly reduction in UF size | Limited data available | Studies to assess its impact on UF size |
| collagenase | Brunengraber 2014;Singh 2021 | Reduction in UFs collagen density | Only one in vivo study identified | Further in vivo studies to assess efficacy and safety |
| Biodegradable thermoresponsive drug delivery systems | Taylor 2011 | Novel drug delivery system | Very limited data on its use in UF | Further studies to assess its efficacy and safety with different drugs |
| Chinese herbal preparations | Lei 2023 | Increased effectiveness of the combined therapy (Guizhi Fuling + mifepristone) vs mifepristone alone | Low quality of available data | High quality randomized trials to prove initial findings |
| Phytochemicals | Islam 2016;Lin 2019 | Isoliquiritigenin causes diminished cell viability, proliferation, induces cell cycle arrest and apoptosis | Limited data | High quality randomized trials to prove initial findings |
| Curcumin | Malik 2023;Tsuiji 2011;Yilmaz 2018 | Inhibition of tumor cell proliferation | Only in vitro and animal studies identified | Further animal and human based studies to assess safety and efficacy |
| Acupuncture | Zheng 2020Zhang 2010 | In Chinese medicine used to prevent and treat various diseases | Effect on UF is to be determined | Ongoing randomized trial |
| UF – uterine fibroid. | ||||