28 March 2024 : Clinical Research
Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Predicting Complete Pathological Response in Rectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy
Mustafa Karaca
1ACDEF, Ece Salim2ABDEF, Mustafa Serkan Alemdar 3BDEF, Özge Deniz Karaca 2BEF, Mustafa Özgür Arıcı 3BDEF*
DOI: 10.12659/MSM.943750
Med Sci Monit 2024; 30:e943750
Table 3 Patient characteristics according to NLR groups.
| Variables | NLR <3.63 (n=137) | NLR >3.63 (n=50) | p |
|---|---|---|---|
| Age (years), mean±SD | 63.47±11.6 | 67.64±9.44 | |
| Gender, n (%) | |||
| Male | 82 (59.9) | 41 (82) | |
| Female | 55 (40.1) | 9 (18) | |
| Comorbid disease, n (%) | 57 (41.6) | 18 (36) | 0.489 |
| Diabetes mellitus | 28 (20.4) | 9 (18) | 0.711 |
| Hypertension | 2 (1.5) | 0 (0) | 0.999 |
| Ulcerative colitis | 26 (19) | 8 (16) | 0.640 |
| Coronary artery disease | 1 (0.7) | 1 (2) | 0.464 |
| Chemotherapy agent, n (%) | |||
| Capecitabine | 82 (59.9) | 14 (28) | |
| 5-FU | 55 (40.1) | 36 (72) | |
| Type of surgery, n (%) | |||
| LAR | 111 (81) | 43 (86) | 0.429 |
| MILES operation | 26 (19) | 7 (14) | |
| Pathological response, n (%) | |||
| Complete response | 25 (18.2) | 9 (18) | |
| Near complete response | 52 (38) | 9 (18) | |
| Partial response | 46 (33.6) | 22 (44) | |
| No response | 14 (10.2) | 10 (20) | |
| Poor response, n (%) | 60 (43.8) | 32 (64) | |
| Hemoglobin at diagnosis, mean±SD | 12.61±2.03 | 12.11±2.14 | 0.145 |
| Platelets at diagnosis, median (IQR) | 276 (239–341) | 288 (220–333) | 0.328 |
| LDH at diagnosis, median (IQR) | 191 (165–228) | 191.5 (163–222) | 0.480 |
| Independent t-test, Mann-Whitney U test, Pearson chi-square test, Fisher’s Exact test. NLR – Neutrophil/lymphocyte ratio; 5-FU – 5-Fluorouracil; LAR – low anterior resection; LDH – lactate dehydrogenase. The same lowercase letters in a row indicate that there is no significant difference between the groups. | |||