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28 March 2024: Clinical Research

Prognostic Significance of Neutrophil-to-Lymphocyte Ratio in Predicting Complete Pathological Response in Rectal Cancer Patients Receiving Neoadjuvant Chemoradiotherapy

Mustafa Karaca 1ACDEF* , Ece Salim 2ABDEF , Mustafa Serkan Alemdar 3BDEF , Özge Deniz Karaca 2BEF , Mustafa Özgür Arıcı 3BDEF

DOI: 10.12659/MSM.943750

Med Sci Monit 2024; 30:e943750

Table 3 Patient characteristics according to NLR groups.

VariablesNLR <3.63 (n=137)NLR >3.63 (n=50)p
Age (years), mean±SD63.47±11.667.64±9.44
Gender, n (%)
 Male82 (59.9)41 (82)
 Female55 (40.1)9 (18)
Comorbid disease, n (%)57 (41.6)18 (36)0.489
 Diabetes mellitus28 (20.4)9 (18)0.711
 Hypertension2 (1.5)0 (0)0.999
 Ulcerative colitis26 (19)8 (16)0.640
 Coronary artery disease1 (0.7)1 (2)0.464
Chemotherapy agent, n (%)
 Capecitabine82 (59.9)14 (28)
 5-FU55 (40.1)36 (72)
Type of surgery, n (%)
 LAR111 (81)43 (86)0.429
 MILES operation26 (19)7 (14)
Pathological response, n (%)
 Complete response25 (18.2)9 (18)
 Near complete response52 (38)9 (18)
 Partial response46 (33.6)22 (44)
 No response14 (10.2)10 (20)
Poor response, n (%)60 (43.8)32 (64)
Hemoglobin at diagnosis, mean±SD12.61±2.0312.11±2.140.145
Platelets at diagnosis, median (IQR)276 (239–341)288 (220–333)0.328
LDH at diagnosis, median (IQR)191 (165–228)191.5 (163–222)0.480
Independent t-test, Mann-Whitney U test, Pearson chi-square test, Fisher’s Exact test. NLR – Neutrophil/lymphocyte ratio; 5-FU – 5-Fluorouracil; LAR – low anterior resection; LDH – lactate dehydrogenase. The same lowercase letters in a row indicate that there is no significant difference between the groups.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750